Protein kinase function of pyruvate kinase M2 and cancer.
Protein kinase function of pyruvate kinase M2 and cancer.
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丙酮酸激酶 M2 的蛋白激酶功能与癌症
DOI：
10.1186/s12935-020-01612-1
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发表时间：
2020-10-29
影响因子：
5.8
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Chen X;Chen S;Yu D
丙酮酸激酶是糖酵解途径中的一种末端酶，它通过底物水平的磷酸化催化磷酸烯醇式丙酮酸转化为丙酮酸并产生三磷酸腺苷。PKM2是丙酮酸激酶的四种亚型之一，广泛表达于多种类型的肿瘤中，与肿瘤的发生密切相关。除了涉及代谢途径的丙酮酸激酶活性外，越来越多的证据表明PKM2在癌症中发挥着非代谢功能。研究表明，PKM2被转位到细胞核中，在那里它作为一种蛋白激酶对各种蛋白靶标进行磷酸化，并参与了多种生理病理过程。我们讨论了PKM2的核定位，它的蛋白激酶功能及其与癌症的关系，以及对PKM2活性的调节。
Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and associated with tumorigenesis. In addition to pyruvate kinase activity involving the metabolic pathway, increasing evidence demonstrates that PKM2 exerts a non-metabolic function in cancers. PKM2 has been shown to be translocated into nucleus, where it serves as a protein kinase to phosphorylate various protein targets and contribute to multiple physiopathological processes. We discuss the nuclear localization of PKM2, its protein kinase function and association with cancers, and regulation of PKM2 activity.
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影响因子：
6.4
作者：
Elena Bravo-Adame, Maria;Vera-Estrella, Rosario;Rosenstein, Yvonne
通讯作者：
Rosenstein, Yvonne
影响因子：
37.3
作者：
Hsu MC;Hung WC
通讯作者：
Hung WC
影响因子：
4.8
作者：
Hoshino, Akemi;Hirst, John A.;Fujii, Hodaka
通讯作者：
Fujii, Hodaka
丙酮酸激酶M2激活剂促进四聚体形成并抑制肿瘤发生。
影响因子：
14.8
作者：
Anastasiou, Dimitrios;Yu, Yimin;Israelsen, William J.;Jiang, Jian-Kang;Boxer, Matthew B.;Hong, Bum Soo;Tempel, Wolfram;Dimov, Svetoslav;Shen, Min;Jha, Abhishek;Yang, Hua;Mattaini, Katherine R.;Metallo, Christian M.;Fiske, Brian P.;Courtney, Kevin D.;Malstrom, Scott;Khan, Tahsin M.;Kung, Charles;Skoumbourdis, Amanda P.;Veith, Henrike;Southall, Noel;Walsh, Martin J.;Brimacombe, Kyle R.;Leister, William;Lunt, Sophia Y.;Johnson, Zachary R.;Yen, Katharine E.;Kunii, Kaiko;Davidson, Shawn M.;Christofk, Heather R.;Austin, Christopher P.;Inglese, James;Harris, Marian H.;Asara, John M.;Stephanopoulos, Gregory;Salituro, Francesco G.;Jin, Shengfang;Dang, Lenny;Auld, Douglas S.;Park, Hee-Won;Cantley, Lewis C.;Thomas, Craig J.;Heiden, Matthew G. Vander
通讯作者：
Heiden, Matthew G. Vander
DOI：
10.1084/jem.20111487
发表时间：
2012-02-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Goldberg MS;Sharp PA
通讯作者：
Sharp PA