Reactive Oxygen Species: The Good and the Bad

Reactive Oxygen Species: The Good and the Bad
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活性氧:好与坏

DOI:
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发表时间:
2017
期刊:
影响因子:
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通讯作者:
W. Chilian
W. Chilian
中科院分区:
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文献类型:
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作者:
Roma Patel;Lindsey Rinker;Joanna Peng;W. Chilian

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本章总结了活性氧(ROS)生物学的最新研究。这一章的重点是活性氧的双峰作用,这可以概括为有益的和消极的。ROS的有益方面与其对细胞氧化还原状态的影响以及某些ROS在信号级联中发挥的重要作用有关。ROS的有害作用是这些化学部分的相关过量,其由内源性抗氧化剂的过量产生和/或作用不足引起。本文还讨论了这些物种的产生。
This chapter summarizes recent research on the biology of reactive oxygen species (ROS). The chapter is focused on the bimodal actions of ROS, which can be summarized as both beneficial and negative. The beneficial aspects of ROS are related to their effects on the redox state of cells and the important role that some ROS play in signaling cascade. The detrimental effects of ROS are related excess amounts of these chemical moieties, which are caused by excessive production and/or insufficient actions of endogenous antioxi -dants. The generation of these species is also discussed.
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