PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome.
PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome.
复制标题
肝内胆管癌中的 PD-1/PD-L1 表达谱可预测临床结果
DOI：
10.1186/s12957-020-02082-5
复制
发表时间：
2020-11-23
影响因子：
3.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Tian L;Ma J;Ma L;Zheng B;Liu L;Song D;Wang Y;Zhang Z;Gao Q;Song K;Wang X
已观察到靶向程序性细胞死亡蛋白-1（PD-1）/程序性细胞死亡蛋白配体1（PD-L1）途径的免疫疗法在几种实体瘤中有效。我们的目的是探讨PD-1/PD-L1表达谱在肝内胆管细胞癌（ICC）中的预后意义。我们使用基于酪胺信号放大（TSA）的多重免疫组织化学研究了322例ICC患者配对肿瘤和邻近正常组织中PD-1、PD-L1、CD 8 + T细胞和CD 68+巨噬细胞的表达。我们发现肿瘤浸润的CD 8 + PD-1+ T细胞中高比例的CD 8 + PD-1High与晚期TNM分期显著相关（P = 0.035）。CD 8 + PD-1+中CD 8 + PD-1High比例高的ICC患者术后生存率低于低比例患者（P = 0.0037），是影响OS的独立预后因素（P = 0.025）。CD 68 + PD-L1+细胞密度与CD 8 + PD-1High细胞密度呈显著正相关（P < 0.0001，r = 0.5927）。CD 68 + ICC中CD 68 + PD-L1+的比例是OS和TTR的危险因素，但不是预后的独立因素。CD 68 + PD-L1+巨噬细胞和CD 8 + PD-1High T细胞可能协同抑制抗肿瘤免疫。CD 68 + PD-L1+巨噬细胞和CD 8 + PD-1High T细胞预示着ICC预后不良，也可能为ICC的免疫靶向治疗带来新的进展。在线版本包含补充材料，可通过10.1186/s12957-020-02082-5获得。
Immunotherapy targeting the programmed cell death protein-1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) pathway has been observed to be efficient in several solid tumors. We aim to investigate the prognostic significance of PD-1/PD-L1 expression profile in intrahepatic cholangiocarcinoma (ICC). We investigated the expression of PD-1, PD-L1, CD8+ T cells, and CD68+ macrophages in paired tumor and adjacent normal tissues from 322 ICC patients using tyramide signal amplification (TSA)-based multiplexed immunohistochemistry. We found that high proportion of tumor-infiltrating CD8+ PD-1High within CD8+ PD-1+ T cells significantly correlated with advanced TNM stage (P = 0.035). ICC patients with high proportion of CD8+ PD-1High in CD8+ PD-1+ had worse postoperative survival than low proportion patients (P = 0.0037), which was an independently prognostic factor for OS (P = 0.025,). The density of CD68+ PD-L1+ significantly and positively correlated with the density of CD8+ PD-1High (P < 0.0001, r = 0.5927). The proportion of CD68+ PD-L1+ within CD68+ ICC was the risk factor for OS and TTR but not an independently factor for prognosis. The CD68+ PD-L1+ macrophages and CD8+ PD-1High T cells may cooperatively play a role in inhibiting anti-tumor immunity. CD68+ PD-L1+ macrophages and CD8+ PD-1High T cells predict unfavorable prognosis, which could also bring new progress about immune target therapy in ICC research. The online version contains supplementary material available at 10.1186/s12957-020-02082-5.
登录
查看更多内容
程序性死亡配体1的表达模式与肝细胞癌的不同微环境和患者预后相关
影响因子：
8.8
作者：
Liu CQ;Xu J;Zhou ZG;Jin LL;Yu XJ;Xiao G;Lin J;Zhuang SM;Zhang YJ;Zheng L
通讯作者：
Zheng L
DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
CD8 T淋巴细胞上程序性细胞死亡蛋白1表达在胰腺癌中的预后价值
影响因子：
4.6
作者：
Shen T;Zhou L;Shen H;Shi C;Jia S;Ding GP;Cao L
通讯作者：
Cao L
影响因子：
65.1
作者：
Banales, Jesus M.;Cardinale, Vincenzo;Alvaro, Domenico
通讯作者：
Alvaro, Domenico
影响因子：
2.8
作者：
Jiang, Canhua;Yuan, Fulai;Wu, Limeng
通讯作者：
Wu, Limeng