Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.
Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.
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DOI：
10.1007/s00109-012-0991-z
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发表时间：
2013-02
影响因子：
4.7
通讯作者：
Deaglio, Silvia
中科院分区：
文献类型：
--
作者：
Longhi, Maria Serena;Robson, Simon C.;Bernstein, Steven H.;Serra, Sara;Deaglio, Silvia
当存在于细胞外环境中时，核苷腺苷保护细胞和组织免受过度炎症和免疫介导的损伤，同时促进愈合过程。这一作用已经通过使用不同的疾病模型（包括结肠炎、糖尿病、哮喘、败血症和缺血性损伤的疾病模型）进行实验来强调。腺苷还抑制免疫应答，如在肿瘤微环境中，在促进血管生成的同时协助免疫逃避。腺苷信号传导的机制将在本期的其他部分讨论。在这里，作者特别强调从细胞外核苷酸产生腺苷。这一过程是由一系列质膜外核苷酸酶催化的，本文重点介绍了CD39，CD73和CD38家族的成员及其在炎症和肿瘤性血液病中的作用。通过具有或调节外核苷酸酶功能的药物对腺苷生成的药理学调节可用于治疗这些不同的病症。
When present in the extracellular environment, the nucleoside adenosine protects cells and tissues from excessive inflammation and immune-mediated damage while promoting healing processes. This role has been highlighted experimentally using distinct disease models, including those of colitis, diabetes, asthma, sepsis, and ischemic injury. Adenosine also suppresses immune responses, as in the tumor microenvironment, assisting immune evasion while promoting angiogenesis. The mechanisms involved in adenosine signaling are addressed elsewhere in this issue. Here, the authors specifically address the generation of adenosine from extracellular nucleotides. This process is catalyzed by a series of plasma membrane ectonucleotidases, with the focus in this article on members of the CD39, CD73, and CD38 families and on their role in inflammatory and neoplastic hematological diseases. Pharmacological modulation of adenosine generation by drugs that either have or modulate ectonucleotidase function might be exploited to treat these diverse conditions.
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