Primary central nervous system lymphoma in acquired immune deficiency syndrome: A clinical and pathological study
Primary central nervous system lymphoma in acquired immune deficiency syndrome: A clinical and pathological study
复制标题
获得性免疫缺陷综合征中的原发性中枢神经系统淋巴瘤：临床和病理学研究
作者：
Y. So;J. Beckstead;R. Davis
在四年的时间内观察到 20 例与获得性免疫缺陷综合征相关的中枢神经系统原发性淋巴瘤，并进行了临床和病理学研究。活检确诊 11 例，尸检证实 9 例。所有有足够尸检材料的病例均表现出多中心性。大细胞免疫母细胞淋巴瘤和小非裂解淋巴瘤均可见，对 5 名患者的标记物研究证实淋巴瘤源自 B 细胞。回顾了神经系统症状和体征、脑脊液特征和放射学外观。临床和放射学图像是非特异性的，组织学证实对于诊断至关重要。尽管肿瘤看起来对放射敏感，但预后极差，平均生存期不到两个月。
Twenty cases of primary lymphoma of the centratl nervous system associated with acquired immune deficiency syndrome were seen over a period of four years and were studied clinically and pathologically. Biopsy established the diagnosis in 11 cases, and autopsy confirmed it in 9. Multicentricity was demonstrated in all cases for which there was adequate autopsy material. Both large‐cell immunoblastic and small noncleaved lymphomas were seen, and marker studies in 5 patients established that the lymphomas were of B‐cell origin. Neurological symptoms and signs, cerebrospinal fluid characteristics, and radiographic appearance were reviewed. The clinical and radiographic picture is nonspecific and histological confirmation is essential for diagnosis. Although the tumor appears to be radiosensitive, prognosis is extremely poor, with an average survival of less than two months.
使用醛固定塑料包埋切片在人体组织中优化抗原定位。
DOI：
10.1177/33.9.4020104
发表时间：
1985
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Beckstead,JH
通讯作者：
Beckstead,JH
DOI：
10.1056/nejm198309293091301
发表时间：
1983-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
F. Hochberg;G. Miller;R. Schooley;M. Hirsch;P. Feorino;W. Henle
通讯作者：
F. Hochberg;G. Miller;R. Schooley;M. Hirsch;P. Feorino;W. Henle