Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode.
Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode.
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DOI：
10.1109/ner49283.2021.9441420
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Weber DJ
中科院分区：
文献类型：
--
作者：
Dalrymple AN;Ting JE;Bose R;Nieuwoudt S;Franke M;Ludwig KA;Shoffstall AJ;Fisher LE;Weber DJ
慢性疼痛影响着美国数百万人，药物治疗无效。背根神经节（DRG）刺激是一种神经调节方法，其向DRG递送电刺激以缓解疼痛。背根神经节电极是刚性的圆柱形电极。DRG电极的植入需要技术上具有挑战性的手术，该手术涉及将电极侧向转向DRG。注射电极是一种可注射的导电聚合物，可原位固化，能够输送电流刺激神经组织。我们使用注射电极刺激猫的L6和L7 DRG，测量坐骨神经、胫神经和腓总神经中诱发的神经反应，以测量激活纤维的阈值。圆柱形不锈钢电极用于比较。与不锈钢相比，注射电极的耐受性高38%，可能是由于其与DRG的接触表面积更大。刺激DRG可激活Aα和Aβ感觉纤维。注射电极有可能为DRG刺激提供一种新的简单方法，可能提供更完整的DRG覆盖。
Chronic pain affects millions of people in the United States and pharmacological treatments have been ineffective. Dorsal root ganglion (DRG) stimulation is a neuromodulation method that delivers electrical stimulation to the DRG to relieve pain. DRG electrodes are rigid and cylindrical. The implantation of DRG electrodes requires a technically-challenging surgery that involves steering electrodes laterally towards the DRG. The Injectrode is an injectable conductive polymer that cures in place and is capable of delivering electrical current to stimulate neural tissue. We used the Injectrode to stimulate the L6 and L7 DRG in cats, measuring neural responses evoked in the sciatic, tibial, and common peroneal nerves to measure the thresholds for activating fibers. A cylindrical stainless-steel electrode was used for comparison. Thresholds were 38% higher with the Injectrode versus stainless-steel, likely owing to its larger contact surface area with the DRG. Both Aα and Aβ sensory fibers were activated using DRG stimulation. The Injectrode has the potential to offer a new and simple method for DRG stimulation that can potentially offer more complete coverage of the DRG.
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