Pancreatic cancer stem cells: fact or fiction?

Pancreatic cancer stem cells: fact or fiction?
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DOI:
10.1016/j.bbadis.2009.02.007
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发表时间:
2009-04
影响因子:
6.2
通讯作者:
Shay, Jerry W.
Shay, Jerry W.
中科院分区:
生物学2区
文献类型:
--
作者:
Bhagwandin, Vikash J.;Shay, Jerry W.

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The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial–mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.
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