Neural mechanisms of sexual decision-making in women with alcohol use disorder.
Neural mechanisms of sexual decision-making in women with alcohol use disorder.
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DOI：
10.1007/s00213-021-05815-w
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发表时间：
2021-07
影响因子：
3.4
通讯作者：
James TW
中科院分区：
文献类型：
--
作者：
Folco KL;Fridberg DJ;Arcurio LR;Finn PR;Heiman JR;James TW
酒精使用障碍（AUD）的年轻成年女性中，饮酒和性活动同时发生与性侵犯、性传播疾病和意外怀孕的风险增加有关。之前有相当多的工作证明了AUD患者对酒精线索的神经反应。因为饮酒和性行为都是有益的，而且往往是同时发生的，性暗示可能会在AUD女性中产生类似的神经反应，这可能表明对两种暗示的反应有共同的机制。另外，对酒精和性暗示的反应可能是不同的，这表明了特定领域的机制。我们调查了AUD女性在性行为方面的决策脆弱性是否与对照组女性在脑活动方面的差异有关。AUD患者（n = 15）和非AUD患者（n = 16）在fMRI期间完成了一个假设的决策任务，该任务呈现了低或高风险的场景，包括视觉性、食欲和中性线索。结果显示，与对照组相比，患有AUD的女性更容易接受性暗示，并在额叶区、视觉区和奖励区引发不同的大脑激活模式。在高风险决策过程中，与对照组相比，患有AUD的女性未能下调激活，导致过度激活。视觉性线索产生的反应就像之前对酒精线索的反应一样，这表明AUD女性的酒精和性线索反应有一个共同的或普遍的机制。AUD女性更冒险的性行为可能是反复将饮酒和性活动结合在一起的结果，这是该人群的特征行为。
The co-occurrence of alcohol consumption and sexual activity is associated with increased risk for sexual assault, sexually transmitted disease, and unplanned pregnancy among young adult women with alcohol use disorder (AUD). There is considerable previous work demonstrating neural reactivity to alcohol cues in AUD. Because alcohol consumption and sexual behavior are both rewarding and tend to co-occur, sexual cues may produce similar neural reactivity in women with AUD, possibly indicating a shared mechanism underlying reactivity to both types of cues. Alternatively, reactivity to alcohol versus sexual cues may be distinct, suggesting domain-specific mechanisms. We investigated whether the decision vulnerabilities in AUD women regarding sexual activity are related to differences in brain activation compared to control women. Women with (n = 15) and without (n = 16) AUD completed a hypothetical decision-making task during fMRI that presented low- or high-risk scenarios involving visual sexual, appetitive, and neutral cues. Results showed that sexual cues were more often endorsed by women with AUD compared to controls, and elicited differential brain activation patterns in frontal, visual, and reward regions. During high-risk decisions, women with AUD failed to down-regulate activation, causing hyperactivation compared to controls. Visual sexual cues produced reactivity like that previously demonstrated for alcohol cues, suggesting a shared or domain-general mechanism for alcohol and sexual cue reactivity in women with AUD. Riskier sexual decisions in women with AUD may be a consequence of repeatedly pairing alcohol use and sexual activity, a characteristic behavior of this population.
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DOI：
10.1037/adb0000341
发表时间：
2018-03
期刊：
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
影响因子：
--
作者：
Bailey AJ;Gerst K;Finn PR
通讯作者：
Finn PR
影响因子：
2.5
作者：
Rupp HA;James TW;Ketterson ED;Sengelaub DR;Janssen E;Heiman JR
通讯作者：
Heiman JR
影响因子：
4.6
作者：
Chassin, L;Pitts, SC;Todd, M
通讯作者：
Todd, M
DOI：
10.1177/1534582302001003001
发表时间：
2002-09-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
Finn, Peter R
通讯作者：
Finn, Peter R
影响因子：
17.7
作者：
Frazier, JA;Chiu, SF;Biederman, J
通讯作者：
Biederman, J