Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders.
Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders.
复制标题
昼夜节律对Habenula的影响及其对神经精神疾病的潜在贡献。
DOI：
10.3389/fnbeh.2021.815700
复制
发表时间：
2021
影响因子：
3
通讯作者：
Piggins HD
中科院分区：
文献类型：
--
作者：
Young CJ;Lyons D;Piggins HD
神经昼夜节律系统由位于下丘脑视交叉上核（SCN）的主昼夜节律钟组成，它向身体的其他部分（包括也有节奏地表达昼夜节律钟基因的其他大脑区域）传递一天中的时间线索。在过去的16年里，有证据表明，上皮体的缰是一个候选的scn外昼夜节律振荡器。当从SCN中分离时，缰状核维持时钟基因表达和神经元活动的节律，外侧缰状核比相邻的内侧缰状核表达更强劲的节律。侧缰对假定的SCN输出因子以及传递到缰周区域的光信息作出反应。抑郁症患者侧链的神经元活动发生改变，有趣的是，昼夜节律的紊乱会增加患抑郁症等精神健康障碍的风险。在这篇综述中，我们将主要关注昼夜节律和光信号如何影响侧链，并评估这些影响的改变导致精神健康障碍的可能性。
The neural circadian system consists of the master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN) communicating time of day cues to the rest of the body including other brain areas that also rhythmically express circadian clock genes. Over the past 16 years, evidence has emerged to indicate that the habenula of the epithalamus is a candidate extra-SCN circadian oscillator. When isolated from the SCN, the habenula sustains rhythms in clock gene expression and neuronal activity, with the lateral habenula expressing more robust rhythms than the adjacent medial habenula. The lateral habenula is responsive to putative SCN output factors as well as light information conveyed to the perihabenula area. Neuronal activity in the lateral habenula is altered in depression and intriguingly disruptions in circadian rhythms can elevate risk of developing mental health disorders including depression. In this review, we will principally focus on how circadian and light signals affect the lateral habenula and evaluate the possibility that alteration in these influences contribute to mental health disorders.
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DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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