The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.
The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.
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DOI：
10.3390/brainsci13091347
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发表时间：
2023-09-20
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
健康的大脑显示出广泛的射击方式，从慢波睡眠期间的同步振荡到运动过程中的异步射击。这些生理活性与癫痫大脑中病理多动症的时期共存，神经元可以在同步爆发中发射。大多数皮质神经元是具有频率适应的锥体常规峰值（RS）细胞，并且在电流钳实验（体外）中不表现出突发。在这项工作中，我们研究了基于基于电导的皮质RS细胞的电导模型，研究了由于缓慢的钾和钙电流而引起的尖峰到爆发模式的过渡机制。研究了不同的突触耦合（）和外部电流输入（i），研究了钾和钙离子通道对高同步模式的关节影响。我们的结果表明，缓慢的钾电流在高同步活动的出现以及尖峰到爆炸模式过渡中起着重要作用。该过渡与神经元网络的双态动力学有关，在该动力学中，生理异步状态与病理爆发同步共存。尖峰间隔变化系数的磁滞曲线表明，可以通过具有神经元同步的触发状态来启动爆发。此外，我们注意到高阈值（）和低阈值（）离子通道在增加和降低可动力学的参数条件（和i）中起作用。对于高电导值，当神经元弱耦合并接收更多的外部输入时，会出现同步爆发。另一方面，当电导增加时，需要更高的耦合和较低的I对于产生爆发同步。鉴于我们的结果，我们建议通道亚型特异性药理学相互作用可用于诱导从病理高爆发状态到健康状态的过渡。
Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking (RS) cells with frequency adaptation and do not exhibit bursts in current-clamp experiments (in vitro). In this work, we investigate the transition mechanism of spike-to-burst patterns due to slow potassium and calcium currents, considering a conductance-based model of a cortical RS cell. The joint influence of potassium and calcium ion channels on high synchronous patterns is investigated for different synaptic couplings () and external current inputs (I). Our results suggest that slow potassium currents play an important role in the emergence of high-synchronous activities, as well as in the spike-to-burst firing pattern transitions. This transition is related to the bistable dynamics of the neuronal network, where physiological asynchronous states coexist with pathological burst synchronization. The hysteresis curve of the coefficient of variation of the inter-spike interval demonstrates that a burst can be initiated by firing states with neuronal synchronization. Furthermore, we notice that high-threshold () and low-threshold () ion channels play a role in increasing and decreasing the parameter conditions ( and I) in which bistable dynamics occur, respectively. For high values of conductance, a synchronous burst appears when neurons are weakly coupled and receive more external input. On the other hand, when the conductance increases, higher coupling and lower I are necessary to produce burst synchronization. In light of our results, we suggest that channel subtype-specific pharmacological interactions can be useful to induce transitions from pathological high bursting states to healthy states.
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影响因子：
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作者：
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发表时间：
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影响因子：
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