Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging.
Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging.
复制标题
骨骼肌健康和衰老中的线粒体动力学和线粒体自噬。
DOI：
10.3390/ijms22158179
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发表时间：
2021-07-30
影响因子：
5.6
通讯作者：
Gouspillou G
中科院分区：
文献类型：
--
作者：
Leduc-Gaudet JP;Hussain SNA;Barreiro E;Gouspillou G
维持线粒体完整性对于肌肉健康至关重要。事实上，线粒体在多种细胞过程中发挥着至关重要的作用，包括能量供应、Ca2+稳态、逆行信号传导、细胞死亡等。所有含有线粒体的细胞，包括骨骼肌细胞，都会通过多种途径来维持线粒体健康，包括线粒体生物发生、线粒体衍生的囊泡、线粒体动力学（塑造线粒体形态的融合和裂变过程）和线粒体自噬（负责通过自噬去除线粒体的过程）。骨骼肌质量损失（萎缩）是世界范围内的一个主要健康问题，尤其是老年人。目前，还没有治疗方法可以抵消随着衰老而发生的骨骼肌质量和力量的逐渐下降，这一过程被称为肌肉减少症。越来越多的数据，包括我们自己的数据，表明功能失调的线粒体的积累有助于肌肉减少症的发展。最近提出线粒体动力学和线粒体自噬的损伤会导致肌肉减少症。这篇综述总结了关于线粒体动力学和线粒体自噬在骨骼肌健康和肌少症发展中所发挥作用的当前知识状况。我们还强调最近的研究表明，增强骨骼肌的线粒体自噬是预防甚至治疗老年人骨骼肌功能障碍的有希望的治疗靶点。
The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal muscle cells, dispose of several pathways to maintain mitochondrial health, including mitochondrial biogenesis, mitochondrial-derived vesicles, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy—the process in charge of the removal of mitochondria though autophagy. The loss of skeletal muscle mass (atrophy) is a major health problem worldwide, especially in older people. Currently, there is no treatment to counteract the progressive decline in skeletal muscle mass and strength that occurs with aging, a process termed sarcopenia. There is increasing data, including our own, suggesting that accumulation of dysfunctional mitochondria contributes to the development of sarcopenia. Impairments in mitochondrial dynamics and mitophagy were recently proposed to contribute to sarcopenia. This review summarizes the current state of knowledge on the role played by mitochondrial dynamics and mitophagy in skeletal muscle health and in the development of sarcopenia. We also highlight recent studies showing that enhancing mitophagy in skeletal muscle is a promising therapeutic target to prevent or even treat skeletal muscle dysfunction in the elderly.
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