Breaking fat: The regulation and mechanisms of lipophagy.

Breaking fat: The regulation and mechanisms of lipophagy.
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DOI:
10.1016/j.bbalip.2017.06.008
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发表时间:
2017-10
期刊:
Biochimica et biophysica acta. Molecular and cell biology of lipids
影响因子:
--
通讯作者:
Mashek DG
Mashek DG
中科院分区:
其他
文献类型:
--
作者:
Schulze RJ;Sathyanarayan A;Mashek DG

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Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs). While the field of lipophagy research is relatively young, an expansion of research in this area over the past several years has greatly advanced our understanding of lipophagy. Since its original characterization in fasted liver, the contribution of lipophagy is now recognized in various organisms, cell types, metabolic states and disease models. Moreover, recent studies provide exciting new insights into the underlying mechanisms of lipophagy induction as well as the consequences of lipophagy on cell metabolism and signaling. This review summarizes recent work focusing on LDs and lipophagy as well as highlighting challenges and future directions of research as our understanding of lipophagy continues to grow and evolve.
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