Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1.
Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1.
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DOI：
10.1038/s41598-023-45412-9
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发表时间：
2023-11-03
影响因子：
4.6
通讯作者：
Peppa, Dimitra
中科院分区：
文献类型：
--
作者：
Alrubayyi, Aljawharah;Touizer, Emma;Hameiri-Bowen, Dan;Charlton, Bethany;Gea-Mallorqui, Ester;Hussain, Noshin;da Costa, Kelly A. S.;Ford, Rosemarie;Rees-Spear, Chloe;Fox, Thomas A.;Williams, Ian;Waters, Laura;Barber, Tristan J.;Burns, Fiona;Kinloch, Sabine;Morris, Emma;Rowland-Jones, Sarah;McCoy, Laura E.;Peppa, Dimitra
具有适应性的自然杀伤(NK)细胞亚群正在成为疫苗诱导的T和B细胞反应的调节者，并专门针对有助于SARS-CoV-2控制的抗体依赖功能。虽然已知HIV-1感染会影响NK细胞池，但SARS-CoV-2感染和/或疫苗接种对HIV感染者(PLWH)NK细胞反应的额外影响尚不清楚。我们的数据显示，在PLWH中，SARS-CoV-2感染使NK细胞偏向分化/适应性更强的CD57+FcεRIγ−表型。在SARS-CoV-2幼稚PLWH接种后，除了具有细胞毒潜力的CD56明亮群体外，还诱导了类似的亚群。抗体依赖的NK细胞功能在感染后148天表现出对Spike的强健和持久的反应，其中适应性NK细胞的反应更丰富。在SARS-CoV-2暴露者中，第一针疫苗接种后NK细胞反应进一步增强，在第二针疫苗接种后，SARS-CoV-2幼稚PLWH达到高峰。适应性NK细胞的存在与细胞和体液反应的大小有关。这些数据表明，适应性NK细胞的功能可以有效地补充和提高PLWH等潜在更脆弱群体中疫苗诱导的适应性免疫。
Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infection is known to affect the NK cell pool, the additional impact of SARS-CoV-2 infection and/or vaccination on NK cell responses in people living with HIV (PLWH) has remained unexplored. Our data show that SARS-CoV-2 infection skews NK cells towards a more differentiated/adaptive CD57+FcεRIγ− phenotype in PLWH. A similar subset was induced following vaccination in SARS-CoV-2 naïve PLWH in addition to a CD56bright population with cytotoxic potential. Antibody-dependent NK cell function showed robust and durable responses to Spike up to 148 days post-infection, with responses enriched in adaptive NK cells. NK cell responses were further boosted by the first vaccine dose in SARS-CoV-2 exposed individuals and peaked after the second dose in SARS-CoV-2 naïve PLWH. The presence of adaptive NK cells associated with the magnitude of cellular and humoral responses. These data suggest that features of adaptive NK cells can be effectively engaged to complement and boost vaccine-induced adaptive immunity in potentially more vulnerable groups such as PLWH.
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DOI：
10.1016/j.xcrm.2021.100290
发表时间：
2021-06-15
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Anand SP;Prévost J;Nayrac M;Beaudoin-Bussières G;Benlarbi M;Gasser R;Brassard N;Laumaea A;Gong SY;Bourassa C;Brunet-Ratnasingham E;Medjahed H;Gendron-Lepage G;Goyette G;Gokool L;Morrisseau C;Bégin P;Martel-Laferrière V;Tremblay C;Richard J;Bazin R;Duerr R;Kaufmann DE;Finzi A
通讯作者：
Finzi A
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1093/cid/ciaa1605
发表时间：
2021-10-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Geretti AM;Stockdale AJ;Kelly SH;Cevik M;Collins S;Waters L;Villa G;Docherty A;Harrison EM;Turtle L;Openshaw PJM;Baillie JK;Sabin CA;Semple MG
通讯作者：
Semple MG
影响因子：
7.7
作者：
Fielding, Ceri Alan;Sabberwal, Pragati;Williamson, James C.;Greenwood, Edward J. D.;Crozier, Thomas W. M.;Zelek, Wioleta;Seow, Jeffrey;Graham, Carl;Huettner, Isabella;Edgeworth, Jonathan D.;Price, David A.;Morgan, Paul B.;Ladell, Kristin;Eberl, Matthias;Humphreys, Ian R.;Merrick, Blair;Doores, Katie;Wilson, Sam J.;Lehner, Paul J.;Wang, Eddie C. Y.;Stanton, Richard J.
通讯作者：
Stanton, Richard J.
影响因子：
6.4
作者：
Herrera L;Martin-Inaraja M;Santos S;Inglés-Ferrándiz M;Azkarate A;Perez-Vaquero MA;Vesga MA;Vicario JL;Soria B;Solano C;De Paz R;Marcos A;Ferreras C;Perez-Martinez A;Eguizabal C
通讯作者：
Eguizabal C