Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
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DOI：
10.1016/j.xcrm.2021.100290
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发表时间：
2021-06-15
期刊：
影响因子：
--
通讯作者：
Finzi A
中科院分区：
文献类型：
--
作者：
Anand SP;Prévost J;Nayrac M;Beaudoin-Bussières G;Benlarbi M;Gasser R;Brassard N;Laumaea A;Gong SY;Bourassa C;Brunet-Ratnasingham E;Medjahed H;Gendron-Lepage G;Goyette G;Gokool L;Morrisseau C;Bégin P;Martel-Laferrière V;Tremblay C;Richard J;Bazin R;Duerr R;Kaufmann DE;Finzi A
由于最近批准了高效的2019冠状病毒病（COVID-19）疫苗，目前正在研究对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的功能性和持久免疫力，因为在恢复期血浆中的抗体水平显示下降。由于缺乏抗体并不等同于缺乏免疫记忆，因此我们评估了恢复期个体中sars - cov -2特异性记忆B细胞的存在。在这里，我们报告了一项纵向评估32名供者的体液免疫反应，直至症状发作后8个月。我们的观察结果表明，血浆中抗刺突和抗受体结合域（RBD）免疫球蛋白M （IgM）衰减迅速，而IgG的减少不太明显。与fc效应函数相比，中和活性也迅速下降。同时，与rbd特异性IgG+ B细胞相比，rbd特异性IgM+ B细胞的频率显著下降，但保持稳定。我们的研究结果增加了目前对SARS-CoV-2感染后免疫记忆的理解，这对继发性感染的预防和疫苗效果至关重要。尽管总体抗体水平下降，但随着时间的推移，sars - cov -2特异性B细胞免疫持续存在。在一组sars - cov -2康复个体中，Anand等人观察到IgM和中和水平同时下降，尽管IgG和fc -效应功能保持相对稳定。抗原特异性记忆B细胞在所有个体中的存在和持续存在对于长期免疫是令人鼓舞的。
With the recent approval of highly effective coronavirus disease 2019 (COVID-19) vaccines, functional and lasting immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently under investigation as antibody levels in plasma were shown to decline during convalescence. Since the absence of antibodies does not equate to absence of immune memory, we evaluate the presence of SARS-CoV-2-specific memory B cells in convalescent individuals. Here, we report a longitudinal assessment of humoral immune responses on 32 donors up to 8 months post-symptom onset. Our observations indicate that anti-Spike and anti-receptor binding domain (RBD) immunoglobulin M (IgM) in plasma decay rapidly, whereas the reduction of IgG is less prominent. Neutralizing activity also declines rapidly when compared to Fc-effector functions. Concomitantly, the frequencies of RBD-specific IgM+ B cells wane significantly when compared to RBD-specific IgG+ B cells, which remain stable. Our results add to the current understanding of immune memory following SARS-CoV-2 infection, which is critical for secondary infection prevention and vaccine efficacy. Spike-specific IgM and IgA wane more rapidly than IgG after recovery Fc-effector functions, but not neutralization, are sustained over time SARS-CoV-2-specific B cell immunity persists despite overall antibody decline In a cohort of SARS-CoV-2-recovered individuals, Anand et al. observe a concomitant decrease of IgM and neutralization although IgG and Fc-effector functions remain relatively stable. The presence and persistence of antigen-specific memory B cells in all individuals are encouraging with regards to long-term immunity.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
120.7
作者：
Li, Ling;Zhang, Wei;Liu, Zhong
通讯作者：
Liu, Zhong
REGN-COV2抗体预防和治疗恒河猕猴和仓鼠中的SARS-COV-2感染。
DOI：
10.1126/science.abe2402
发表时间：
2020-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Baum A;Ajithdoss D;Copin R;Zhou A;Lanza K;Negron N;Ni M;Wei Y;Mohammadi K;Musser B;Atwal GS;Oyejide A;Goez-Gazi Y;Dutton J;Clemmons E;Staples HM;Bartley C;Klaffke B;Alfson K;Gazi M;Gonzalez O;Dick E Jr;Carrion R Jr;Pessaint L;Porto M;Cook A;Brown R;Ali V;Greenhouse J;Taylor T;Andersen H;Lewis MG;Stahl N;Murphy AJ;Yancopoulos GD;Kyratsous CA
通讯作者：
Kyratsous CA
DOI：
10.1016/j.medj.2021.01.005
发表时间：
2021-03-12
期刊：
Med (New York, N.Y.)
影响因子：
--
作者：
Pradenas E;Trinité B;Urrea V;Marfil S;Ávila-Nieto C;Rodríguez de la Concepción ML;Tarrés-Freixas F;Pérez-Yanes S;Rovirosa C;Ainsua-Enrich E;Rodon J;Vergara-Alert J;Segalés J;Guallar V;Valencia A;Izquierdo-Useros N;Paredes R;Mateu L;Chamorro A;Massanella M;Carrillo J;Clotet B;Blanco J
通讯作者：
Blanco J
影响因子：
64.5
作者：
Moderbacher, Carolyn Rydyznski;Ramirez, Sydney, I;Crotty, Shane
通讯作者：
Crotty, Shane