Emerging roles of p53 in glial cell function in health and disease.
Emerging roles of p53 in glial cell function in health and disease.
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DOI：
10.1002/glia.22268
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发表时间：
2012-04
期刊：
影响因子：
6.2
通讯作者：
Pocock, Jennifer M.
中科院分区：
文献类型：
--
作者：
Jebelli, Joseph D.;Hooper, Claudie;Garden, Gwenn A.;Pocock, Jennifer M.
新出现的证据表明，p53，一种主要参与癌症生物学的肿瘤抑制蛋白，在CNS中协调广泛的新功能，包括介导神经退行性疾病发病机制的途径。此外，在细胞和分子神经科学的一个不断发展的概念是，神经胶质细胞是更根本的疾病进展比以前认为，这可能是通过一个非细胞自主机制，这是严重依赖于p53的活动。作为连接许多细胞内控制途径（包括细胞周期控制和细胞凋亡）的关键枢纽，p53被理想地放置以协调细胞对一系列应激的反应。虽然神经退行性疾病各自显示出不同的和多样的分子病理学，但细胞凋亡是广泛的标志性特征，并且p53系统协调细胞凋亡和神经胶质细胞行为的多模式能力突出了p53作为神经退行性疾病治疗干预的潜在统一靶点。
Emerging evidence suggests that p53, a tumor suppressor protein primarily involved in cancer biology, coordinates a wide range of novel functions in the CNS including the mediation of pathways underlying neurodegenerative disease pathogenesis. Moreover, an evolving concept in cell and molecular neuroscience is that glial cells are far more fundamental to disease progression than previously thought, which may occur via a noncell-autonomous mechanism that is heavily dependent on p53 activities. As a crucial hub connecting many intracellular control pathways, including cell-cycle control and apoptosis, p53 is ideally placed to coordinate the cellular response to a range of stresses. Although neurodegenerative diseases each display a distinct and diverse molecular pathology, apoptosis is a widespread hallmark feature and the multimodal capacity of the p53 system to orchestrate apoptosis and glial cell behavior highlights p53 as a potential unifying target for therapeutic intervention in neurodegeneration.
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