A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis.
A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis.
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DOI：
10.1002/art.34482
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发表时间：
2012-09
影响因子：
--
通讯作者：
Medsger, Thomas A., Jr.
中科院分区：
文献类型：
--
作者：
Steen, Virginia;Domsic, Robyn T.;Lucas, Mary;Fertig, Noreen;Medsger, Thomas A., Jr.
流行病学研究表明，系统性硬化症更常见，发病年龄更小，在非裔美国人中比高加索人更严重。然而，硬皮病自身抗体谱在这两个种族亚群之间有很大的不同。这项研究考察了非裔美国人和高加索人SSC患者的人口学和疾病特征、内脏系统受累的频率和严重程度以及生存率，并特别关注他们的血清自身抗体谱。作为匹兹堡硬皮病数据库的一部分，研究了1972至2007年间被视为匹兹堡硬皮病数据库一部分的连续非裔美国人和高加索人患者的人口统计学、临床、自身抗体、器官受累和生存的自然病史。采用Medsger疾病严重程度量表判定病情严重程度。非裔美国人患者更有可能出现抗拓扑异构酶、抗U1RNP和U3RNP自身抗体。将非洲裔美国人和高加索人与这些抗体进行比较，具有抗拓扑异构酶抗体的非裔美国人患者比高加索人更频繁、更严重的肺纤维化，并且相关的存活率下降。U1RNP患者的肺纤维化也更严重，但与非裔美国人和高加索人之间的存活率差异无关。与高加索人相比，非裔美国人中抗U3RNP与更严重的胃肠道损害有关。患有系统性硬化症的非裔美国人比高加索人有更严重的疾病并发症，这既是因为他们拥有的自身抗体类型，也是因为他们即使在抗体亚群中也有更严重的间质性肺部疾病。对所有患有间质性肺病的非裔美国人进行早期积极干预应该是优先事项。
Epidemiology studies suggest that Systemic Sclerosis is more common, occurs at a younger age and is more severe in African-Americans than Caucasians. However, the scleroderma autoantibody profile is very different between these two ethnic subgroups. This study examines the demographic and disease features, frequency and severity of internal organ system involvement and survival in African-American and Caucasian SSc patients with particular attention to their serum autoantibody profiles. Demographic, clinical, autoantibody, natural history of organ involvement and survival were studied in consecutive African-American and Caucasian patients seen between 1972 and 2007 as part of the Pittsburgh Scleroderma Database. The Medsger Disease Severity Scale was used to determine severe disease. African-American patients were more likely to have anti topoisomerase, anti U1RNP and U3 RNP auto-antibodies. Comparing African-American and Caucasians with these antibodies, African-American patients with anti topoisomerase antibody had more frequent and more severe pulmonary fibrosis than Caucasians and an associated decreased survival. Pulmonary fibrosis was also more severe in the U1 RNP patients but was not associated with a difference in survival between African Americans and Caucasians. Anti U3 RNP was associated with more severe gastrointestinal involvement in African-American’s compared to Caucasians. African Americans with systemic sclerosis have more severe disease complications than Caucasians both because of the type of autoantibody they have and because they have more severe interstitial lung disease even within the antibody subset. Early aggressive intervention in all African Americans with interstitial lung disease should be a priority.
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影响因子：
3.9
作者：
Sharif, Roozbeh;Fritzler, Marvin J.;Arnett, Frank C.
通讯作者：
Arnett, Frank C.
DOI：
10.1002/art.22532
发表时间：
2007-03-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
McNearney, Terry A.;Reveille, John D.;Mayes, Maureen D.
通讯作者：
Mayes, Maureen D.
影响因子：
--
作者：
Steen, VD;Oddis, CV;Medsger, TA
通讯作者：
Medsger, TA
影响因子：
39.2
作者：
OKANO, Y;STEEN, VD;MEDSGER, TA
通讯作者：
MEDSGER, TA
影响因子：
27.4
作者：
Steen, Virginia D.;Medsger, Thomas A.
通讯作者：
Medsger, Thomas A.