Lipid Metabolic Alterations in the ALS-FTD Spectrum of Disorders.
Lipid Metabolic Alterations in the ALS-FTD Spectrum of Disorders.
复制标题
DOI：
10.3390/biomedicines10051105
复制
发表时间：
2022-05-10
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In ALS these alterations are well described and evident not only with the progression of the disease but also years before diagnosis. Still, there are some discrepancies in findings relating to the causal nature of lipid metabolic alterations, partly due to the great clinical heterogeneity in ALS. ALS presentation is within a disorder spectrum with Frontotemporal Dementia (FTD), and many patients present mixed forms of ALS and FTD, thus increasing the variability. Lipid metabolic and other systemic metabolic alterations have not been well studied in FTD, or in ALS–FTD mixed forms, as has been in pure ALS. With the recent development in lipidomics and the integration with other -omics platforms, there is now emerging data that not only facilitates the identification of biomarkers but also enables understanding of the underlying pathological mechanisms. Here, we reviewed the recent literature to compile lipid metabolic alterations in ALS, FTD, and intermediate mixed forms, with a view to appraising key commonalities or differences within the spectrum.
登录
查看更多内容
影响因子：
4.6
作者：
Area-Gomez E;Larrea D;Yun T;Xu Y;Hupf J;Zandkarimi F;Chan RB;Mitsumoto H
通讯作者：
Mitsumoto H
影响因子：
5.3
作者：
Dodge, James C.;Jensen, Elizabeth H.;Shihabuddin, Lamya S.
通讯作者：
Shihabuddin, Lamya S.
影响因子：
6.9
作者：
Adamo, Kristi B.;Dent, Robert;Tesson, Frederique
通讯作者：
Tesson, Frederique
影响因子：
5.3
作者：
Deguise, Marc-Olivier;Baranello, Giovanni;Kothary, Rashmi
通讯作者：
Kothary, Rashmi
影响因子：
1.6
作者：
Chang MC;Kwak SG;Park JS;Park D
通讯作者：
Park D