Development of a quality-of-life questionnaire for adults with strabismus.
Development of a quality-of-life questionnaire for adults with strabismus.
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DOI：
10.1016/j.ophtha.2008.08.043
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发表时间：
2009-01
期刊：
影响因子：
13.7
通讯作者：
Holmes JM
中科院分区：
文献类型：
--
作者：
Hatt SR;Leske DA;Bradley EA;Cole SR;Holmes JM
我们报告了一个病人的发展，健康相关的生活质量（HRQOL）问卷的成人斜视。横断面研究。在第一阶段中有29名斜视患者，在第二阶段中有32名斜视患者，18名患有其他眼部疾病的患者和13名视力正常的成年人。个体患者访谈产生了181个问卷项目。为了减少项目，我们要求29名斜视患者完成181项问卷，分析回答，并进行因素分析。确定了两个突出的因素，并选择了与每个因素相关性最高的10个项目。最终的20项问卷（10个“社会心理”项目，10个“功能”项目）管理额外的32例斜视患者（22例复视，10例无复视），13名视力正常的成年人，和18例其他眼病。使用5分Likert型量表进行回答（“从不”=100，“很少”= 75，“有时”= 50，“经常”= 25，“总是”= 0）。比较各组的中位总体问卷评分和心理社会和功能子量表评分，范围为0（最差HRQOL）至100（最佳HRQOL）。HRQOL问卷应答评分。斜视患者的中位总分（56分）在统计学上显著低于视力正常成人（95分; P<0.001）和其他眼病患者（86分; P<0.001）。斜视患者的心理社会子量表中位评分（69分）显著低于视力正常成人（99分; P<0.001）和其他眼病患者（94分; P<0.001）。对于功能子量表，斜视患者的中位评分（43）再次显著低于视力正常成人（91; P<0.001）和其他眼病患者（78; P<0.001）。我们已经开发了一个20项，患者衍生的HRQOL问卷，专门为成人斜视，与子量表，以评估心理社会和功能问题。这20项，条件特定的问卷将是有用的评估HRQOL在个别斜视患者，也作为临床试验的结果措施。
We report the development of a patient-derived, health related quality of life (HRQOL) questionnaire for adults with strabismus. Cross-sectional study. 29 patients with strabismus in a first phase, and 32 patients with strabismus, 18 patients with other eye diseases, and 13 visually normal adults in a second phase. Individual patient interviews generated 181 questionnaire items. For item reduction, we asked 29 patients with strabismus to complete the 181-item questionnaire, analyzed responses, and performed factor analysis. Two prominent factors were identified, and the 10 items with the highest correlation with each factor were selected. The final 20-item questionnaire (10 ‘psychosocial’ items, 10 ‘function’ items) was administered to an additional 32 patients with strabismus (22 with diplopia, 10 without diplopia), 13 visually normal adults, and 18 patients with other eye diseases. A 5-point Likert-type scale was used for responses (‘never’=100, ‘rarely’=75, ‘sometimes’=50, ‘often’=25, and ‘always’=0). Median overall questionnaire scores and psychosocial and function sub-scale scores, ranging from 0 (worst HRQOL) to 100 (best HRQOL), were compared across groups. HRQOL questionnaire response scores. Median overall scores were statistically significantly lower (worse quality of life) for patients with strabismus (56) compared to visually normal adults (95; P<0.001) and patients with other eye diseases (86; P<0.001). Median scores on the psychosocial sub-scale were significantly lower for strabismus patients (69) compared to visually normal adults (99; P<0.001) and patients with other eye diseases (94; P<0.001). For the function sub-scale, median scores were again significantly lower for strabismus patients (43) compared to visually normal adults (91; P<0.001) and patients with other eye diseases (78; P<0.001). We have developed a 20-item, patient-derived HRQOL questionnaire specific for adults with strabismus, with sub-scales to assess psychosocial and function concerns. This 20-item, condition specific questionnaire will be useful for assessing HRQOL in individual strabismus patients and also as an outcome measure for clinical trials.
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