The transcriptional landscape of Arabidopsis thaliana pattern-triggered immunity.
The transcriptional landscape of Arabidopsis thaliana pattern-triggered immunity.
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拟南芥模式触发免疫的转录景观。
DOI：
10.1038/s41477-021-00874-5
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发表时间：
2021-05
期刊：
影响因子：
18
通讯作者：
Zipfel C
中科院分区：
文献类型：
--
作者：
Bjornson M;Pimprikar P;Nürnberger T;Zipfel C
植物根据环境条件调整自己的新陈代谢，部分是通过识别一系列广泛的自我和非自我分子。特别是，细胞表面定位的模式识别受体(PRRs)对微生物或植物来源的分子模式的感知会诱导模式触发免疫，其中包括大量的转录重新编程。虽然越来越多的植物PRR和相应的配体已知，但植物是否调整它们的免疫输出以适应不同生物起源或不同生化性质的模式仍不清楚。在这里，我们在早期的时间序列中进行了详细的转录分析，重点研究了模式植物拟南芥中由特征良好的模式诱导的快速信号转录输出。这表明，对不同模式的转录反应--与其来源、生化性质或PRR类型无关--是显著一致的。此外，许多最迅速和通常被模式上调的基因也是由非生物胁迫诱导的，这表明对模式的早期转录反应是植物一般胁迫反应(GSR)的一部分。因此，植物细胞最初的反应主要是对危险的反应。值得注意的是，GSR的遗传损伤降低了模式诱导的抗细菌免疫，证实了这种最初的危险反应的生物学相关性。重要的是，对模式反应常见和特异的一小部分核心免疫反应基因的定义揭示了以前未知的谷氨酸受体样钙离子通透通道在免疫中的功能。因此，这项研究阐明了早期免疫转录重编程的一般和独特特性，揭示了植物免疫的重要组成部分。
Plants tailor their metabolism to environmental conditions, in part through recognition of a wide array of self and non-self molecules. In particular, the perception of microbial or plant-derived molecular patterns by cell surface-localized pattern recognition receptors (PRRs) induces pattern-triggered immunity, which includes massive transcriptional reprogramming. While an increasing number of plant PRRs and corresponding ligands are known, whether plants tune their immune outputs to patterns of different biological origins or of different biochemical nature remains mostly unclear. Here, we performed a detailed transcriptomic analysis in an early time-series focused to study rapid signaling transcriptional outputs induced by well-characterized patterns in the model plant Arabidopsis thaliana. This revealed that the transcriptional response to diverse patterns – independent of their origin, biochemical nature, or type of PRR – is remarkably congruent. Moreover, many of the genes most rapidly and commonly up-regulated by patterns are also induced by abiotic stresses, suggesting that the early transcriptional response to patterns is part of the plant general stress response (GSR). As such, plant cells’ response is in the first instance mostly to danger. Notably, genetic impairment of the GSR reduces pattern-induced anti-bacterial immunity, confirming the biological relevance of this initial danger response. Importantly, the definition of a small subset of ‘core immunity response’ genes common and specific to pattern response revealed the function of previously uncharacterized GLUTAMATE RECEPTOR-LIKE (GLR) calcium-permeable channels in immunity. This study thus illustrates general and unique properties of early immune transcriptional reprogramming that uncovered important components of plant immunity.
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影响因子：
3.5
作者：
Goehre, Vera;Jones, Alexandra M. E.;Weber, Andreas P. M.
通讯作者：
Weber, Andreas P. M.
DOI：
10.1111/tpj.12620
发表时间：
2014-10
期刊：
The Plant journal : for cell and molecular biology
影响因子：
--
作者：
Benn G;Wang CQ;Hicks DR;Stein J;Guthrie C;Dehesh K
通讯作者：
Dehesh K
影响因子：
3.7
作者：
Bates GW;Rosenthal DM;Sun J;Chattopadhyay M;Peffer E;Yang J;Ort DR;Jones AM
通讯作者：
Jones AM
影响因子：
7.2
作者：
Fan, Jun;Crooks, Casey;Lamb, Chris
通讯作者：
Lamb, Chris
影响因子：
7.2
作者：
Birkenbihl, Rainer P.;Kracher, Barbara;Somssich, Imre E.
通讯作者：
Somssich, Imre E.