Differentiating tremor patients using spiral analyses
Differentiating tremor patients using spiral analyses
复制标题
使用螺旋分析区分震颤患者
DOI：
10.1109/embc.2015.7319815
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
G. Deuschl
中科院分区：
文献类型：
--
作者：
N. Koirala;M. Muthuraman;T. Anjum;C.V. Chaitanya;V.F. Helmolt;K. G. Mideksa;K. Lange;G. Schmidt;S. Schneider;G. Deuschl
大多数患者的特发性震颤遵循常染色体显性遗传类型，但其遗传基础尚未确定。这种震颤的发病年龄是双峰的，一种发生在年轻时，另一种发生在年老时。本研究将老年性震颤称为老年性震颤。这两种震颤的确切病理学仍未完全了解。我们希望开发一种简单的诊断工具来在临床上区分这两种震颤。在这项研究中，要求 30 名患者绘制螺旋，每组 15 名。使用 Wacom intuos 版本 4 平板电脑以数字方式记录每只手的螺旋，无论是否有螺旋模板。该研究的目的是从这些螺旋中寻找简单的诊断措施，以区分两组患者。第一个衡量标准是使用众所周知的临床评分，例如没有模板的完整圆圈的数量、宽度、高度、轴和严重程度。第二项措施是估计频域中位置、速度和加速度数据的峰值频率和峰值幅度。除了严重程度有显着差异外，大多数众所周知的临床评分在两个患者队列之间没有显示出任何显着差异。两组患者之间大多数数据的峰值频率和峰值幅度没有显着差异，只有加速度数据的峰值幅度显示出显着差异。因此，我们可以使用这两个参数来区分两个震颤患者组，这将是一种简单的临床诊断工具，无需任何复杂的分析。
Essential tremor follows an autosomal dominant type of inheritance in the majority of patients, yet its genetic basis has not been identified. The age of onset in this tremor is bimodal, one in young age and another when they are old. The old onset is referred to as senile tremor in this study. The precise pathology is still not completely understood for both these tremors. We wanted to develop an easy diagnostic tool to differentiate these two tremors clinically. In this study, the spirals were asked to be drawn by 30 patients, 15 from each group. The spirals were recorded digitally from each hand, with and without the spiral template, using a Wacom intuos version 4 tablets. The aim of the study was to look at the easy diagnostic measures from these spirals to distinguish the two cohorts of patients. The first measure was to use the well-known clinical scores like the number of complete circles without the template, width, height, axis, and degree of severity. The second measure was to estimate the peak frequency and the peak amplitude for the position, velocity, and acceleration data, in the frequency domain. The well-known clinical scores, most of them, did not show any significant difference between the two patient cohorts except the degree of severity which showed significant difference. The peak frequency and the peak amplitude in most of the data were not significantly different between the two cohorts of patients, only the peak amplitude from the acceleration data showed significant difference. Thus, we could use these two parameters to differentiate between the two tremors patient groups, which would be an easy clinical diagnostic tool without the need for any complicated analyses.
螺旋分析：使用数字化平板测量震颤的新技术
影响因子：
8.6
作者：
S. Pullman
通讯作者：
S. Pullman