Plasma concentrations of tumor necrosis factor‐α (TNF‐α) and soluble TNF receptors in patients with bulimia nervosa
Plasma concentrations of tumor necrosis factor‐α (TNF‐α) and soluble TNF receptors in patients with bulimia nervosa
复制标题
神经性贪食症患者血浆肿瘤坏死因子-α (TNF-α) 和可溶性 TNF 受体浓度
DOI：
10.1046/j.1365-2265.2000.01091.x
复制
发表时间：
2000
影响因子：
3.2
通讯作者：
F. Kurimoto
中科院分区：
文献类型：
--
作者：
Y. Nakai;S. Hamagaki;R. Takagi;A. Taniguchi;F. Kurimoto
肿瘤坏死因子-α（TNF-α）是一种具有多种免疫和代谢活性的细胞因子。此外，TNF-α可以刺激中枢神经系统的各种生理、神经内分泌和行为反应。在实验动物中，TNF-α诱导生理和行为参数的变化，这也在进食障碍中观察到。TNF-α的生物活性由两种结构相关但功能不同的受体TNF-RI和TNF-RII介导。由于注射TNF-α导致TNF-α受体脱落增加，因此TNF-α释放可能通过可溶性TNF-受体（sTNF-R）水平反映。
Tumor necrosis factor‐α (TNF‐α) is a cytokine with numerous immunological and metabolic activities. In addition, TNF‐α can stimulate a variety of physiological, neuroendocrine and behavioural responses of the central nervous system. In experimental animals, TNF‐α induces changes in physiological and behavioural parameters which have also been observed in eating disorders. The biological activities of TNF‐α are mediated by two structurally related, but functionally distinct receptors, TNF‐RI and TNF‐RII. Since injection of TNF‐α results in increased shedding of TNF‐α receptors, it is likely that TNF‐α release is reflected by soluble TNF‐receptors (sTNF‐Rs) levels.
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
影响因子：
15.9
作者：
Schreyer, SA;Chua, SC;LeBoeuf, RC
通讯作者：
LeBoeuf, RC
人重组肿瘤坏死因子通过外周作用介导大鼠厌食症。
影响因子：
11.2
作者：
Bodnar,RJ;Pasternak,GW;Mann,PE;Paul,D;Warren,R;Donner,DB
通讯作者：
Donner,DB