Temporal organisation of the brain's intrinsic motor network: The relationship with circadian phenotype and motor performance.
Temporal organisation of the brain's intrinsic motor network: The relationship with circadian phenotype and motor performance.
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DOI：
10.1016/j.neuroimage.2021.117840
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发表时间：
2021-05-15
期刊：
影响因子：
5.7
通讯作者：
Bagshaw AP
中科院分区：
文献类型：
--
作者：
Facer-Childs ER;de Campos BM;Middleton B;Skene DJ;Bagshaw AP
运动网络（MN）的功能连接（FC）常被用于研究大脑的内在特性如何与运动能力和表现相关联。此外，运动网络在临床工作中是描绘中风后恢复情况以及帮助理解神经退行性疾病的一个关键特征。然而，在研究功能连接时，尚未综合考虑昼夜节律时间的日间变化以及个体差异。
共有33名健康的右利手个体（13名男性，年龄23.1 ± 4.2岁）参与了这项研究。使用活动记录仪、睡眠日记以及昼夜节律相位标记物（暗光下褪黑素起始分泌和皮质醇觉醒反应）来确定早期（ECP，n = 13）和晚期（LCP，n = 20）昼夜节律表型组。在14:00、20:00和08:00进行静息态功能磁共振成像测试，在此之前进行等长握力的最大自主收缩测试以测量运动表现。
研究发现早期和晚期昼夜节律表型组之间运动网络的功能连接存在显著差异，并且在一天中的不同时间之间也存在显著变化。与早期昼夜节律表型组相比，晚期昼夜节律表型组的功能连接和表现的日间变化幅度更大，其中早晨受到的影响最为显著。总体而言，较低的功能连接与较差的运动表现显著相关。
我们的研究结果揭示了一天中不同时间以及昼夜节律表型组之间的内在差异。这表明中枢机制导致了运动表现的日间变化，并且静息状态下运动网络的功能完整性影响了在运动任务中的执行能力。
Functional connectivity (FC) of the motor network (MN) is often used to investigate how intrinsic properties of the brain are associated with motor abilities and performance. In addition, the MN is a key feature in clinical work to map the recovery after stroke and aid the understanding of neurodegenerative disorders. Time of day variation and individual differences in circadian timing, however, have not yet been considered collectively when looking at FC. A total of 33 healthy, right handed individuals (13 male, 23.1 ± 4.2 years) took part in the study. Actigraphy, sleep diaries and circadian phase markers (dim light melatonin onset and cortisol awakening response) were used to determine early (ECP, n = 13) and late (LCP, n = 20) circadian phenotype groups. Resting state functional MRI testing sessions were conducted at 14:00 h, 20:00 h and 08:00 h and preceded by a maximum voluntary contraction test for isometric grip strength to measure motor performance. Significant differences in FC of the MN between ECPs and LCPs were found, as well as significant variations between different times of day. A higher amplitude in diurnal variation of FC and performance was observed in LCPs compared to ECPs, with the morning being most significantly affected. Overall, lower FC was significantly associated with poorer motor performance. Our findings uncover intrinsic differences between times of day and circadian phenotype groups. This suggests that central mechanisms contribute to diurnal variation in motor performance and the functional integrity of the MN at rest influences the ability to perform in a motor task.
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