Diurnal Variations in Neural Activity of Healthy Human Brain Decoded with Resting-State Blood Oxygen Level Dependent fMRI.
Diurnal Variations in Neural Activity of Healthy Human Brain Decoded with Resting-State Blood Oxygen Level Dependent fMRI.
复制标题
DOI：
10.3389/fnhum.2016.00634
复制
发表时间：
2016
影响因子：
2.9
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Jiang C;Yi L;Su S;Shi C;Long X;Xie G;Zhang L
人类大脑的神经活动是如何随着昼夜节律的变化而变化的，这仍是一个正在进行的研究。静息状态功能磁共振成像（RS-fMRI）反映了人类大脑的自发活动和/或内源性神经生理过程。在本研究中，我们应用基于RS-fMRI的区域均匀性（ReHo）和低频波动幅度（ALFF）来探讨在24小时时间周期内，早晨和晚上整个大脑自发活动的区域差异。广泛分布的大脑区域表现出昼夜变化，这可能归因于生物钟基因调节的内部分子系统，以及包括明暗循环、日常活动和稳态睡眠驱动在内的环境因素。值得注意的是，默认模式网络（DMN）的日变化表明，在DMN的子区域内存在一种适应或补偿响应，这意味着这些区域之间的调节存在平衡或解耦。
It remains an ongoing investigation about how the neural activity alters with the diurnal rhythms in human brain. Resting-state functional magnetic resonance imaging (RS-fMRI) reflects spontaneous activities and/or the endogenous neurophysiological process of the human brain. In the present study, we applied the ReHo (regional homogeneity) and ALFF (amplitude of low frequency fluctuation) based on RS-fMRI to explore the regional differences in the spontaneous cerebral activities throughout the entire brain between the morning and evening sessions within a 24-h time cycle. Wide spread brain areas were found to exhibit diurnal variations, which may be attributed to the internal molecular systems regulated by clock genes, and the environmental factors including light-dark cycle, daily activities and homeostatic sleep drive. Notably, the diurnal variation of default mode network (DMN) suggests that there is an adaptation or compensation response within the subregions of DMN, implying a balance or a decoupling of regulation between these regions.
登录
查看更多内容
影响因子：
5.7
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.
DOI：
10.1073/pnas.1010666108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Duffy, Jeanne F.;Cain, Sean W.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume
影响因子：
4.8
作者：
van Buuren, Mariet;Gladwin, Thomas E.;Vink, Matthijs
通讯作者：
Vink, Matthijs
影响因子：
2.8
作者：
Marek, Tadeusz;Fafrowicz, Magdalena;Domagalik, Aleksandra
通讯作者：
Domagalik, Aleksandra