Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma.
Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma.
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DOI：
10.5732/cjc.011.10364
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发表时间：
2012-05
影响因子：
--
通讯作者：
Guan XY
中科院分区：
文献类型：
--
作者：
Chen J;Fu L;Zhang LY;Kwong DL;Yan L;Guan XY
鼻咽癌是中国南方最常见的恶性肿瘤之一。在鼻咽癌复杂的发病过程中，基因组DNA的缺失是肿瘤抑制基因失活的关键机制。在许多情况下，tsg的缺失可以作为癌症的诊断和预后指标。3号染色体短臂（3p）是鼻咽癌中最常缺失的染色体区域，其中3p21.1-21.2和3p25.2-26.1是最常缺失的最小区域。近年来，本课课组等在NPC的发生发展过程中，重点研究了RASSF1A、BLU、RBMS3、CHL1等新的3p靶点tsg的鉴定和表征。在这篇综述中，我们总结了最近发现的位于3p的TSGs基因，并详细讨论了其中的一些基因。更好地了解TSGs的3p位点将大大提高我们对鼻咽癌发病机制、诊断和治疗的认识。
Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1–21.2 and 3p25.2–26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
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影响因子：
37.3
作者：
Hill VK;Hesson LB;Dansranjavin T;Dallol A;Bieche I;Vacher S;Tommasi S;Dobbins T;Gentle D;Euhus D;Lewis C;Dammann R;Ward RL;Minna J;Maher ER;Pfeifer GP;Latif F
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
Scarpa, Aldo