Changes in lymphocyte and macrophage subsets due to morphine and ethanol treatment during a retrovirus infection causing murine AIDS.
Changes in lymphocyte and macrophage subsets due to morphine and ethanol treatment during a retrovirus infection causing murine AIDS.
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在导致小鼠艾滋病的逆转录病毒感染过程中，吗啡和乙醇治疗导致淋巴细胞和巨噬细胞亚群发生变化。
DOI：
10.1016/0024-3205(88)90145-2
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Tom L. Smith
中科院分区：
文献类型：
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作者：
Ronald R. Watson;Rao H. Prabhala;H. Darban;M. D. Yahya;Tom L. Smith;Tom L. Smith
LP-BM 5鼠白血病病毒（MuLV）感染显著抑制了显示巨噬细胞、淋巴细胞和活化淋巴细胞表面标志物的外周血细胞的百分比。雌性C57 BL/6小鼠长期给予7%（36%卡路里）乙醇饮食或注射1.9 mg/小鼠/天吗啡7天，随后禁欲3周，然后1周食用5%乙醇饮食或注射吗啡，导致巨噬细胞和淋巴细胞亚群数量变化。各亚群淋巴细胞的数量无显着变化的乙醇暴露，除了那些显示活化标志物减少。显示巨噬细胞功能标志物及其活化的外周血细胞百分比在“狂欢”使用乙醇后显著降低。乙醇延缓逆转录病毒感染对细胞的抑制。然而，到感染25周时，在用逆转录病毒感染的乙醇喂养的小鼠中有8.6%的存活率，这远低于病毒感染的对照组（45.0%）。吗啡治疗还增加了病毒感染小鼠中具有巨噬细胞和活化巨噬细胞标记的细胞的百分比，同时抑制了未感染小鼠中的巨噬细胞和活化巨噬细胞。第二次和第三次吗啡注射系列抑制淋巴细胞T辅助细胞和T抑制细胞，但不总T细胞。然而，在逆转录病毒病期间，吗啡的抑制作用明显低于仅由病毒引起的抑制作用。在感染25周时，44.8%的吗啡治疗的感染小鼠存活。吗啡处理也引起死亡，使得吗啡处理、逆转录病毒感染的存活率高于如果在联合处理期间合并病毒感染和吗啡注射的动物的死亡率的预期。因此，这些药物的滥用可以调节外周血淋巴细胞亚群，抑制引起的逆转录病毒感染，和生存。
Infection by LP-BM5 murine leukemia virus (MuLV) suppressed significantly the percentage of peripheral blood cells showing surface markers for macrophages, lymphocytes and activated lymphoid cells. Chronic administration of a 7% (36% calories) ethanol diet or injection of 1.9 mg/mouse/day of morphine for a 7 day period were followed by 3 week periods of abstinence and then 1 week periods of consumption of 5% ethanol diets or morphine injection to female C57BL/6 mice resulted in changes in the numbers of macrophages and lymphocyte subsets. The number of lymphocytes of various subsets were not significantly changed by the ethanol exposure except those showing activation markers which were reduced. The percentage of peripheral blood cells showing markers for macrophage functions and their activation were significantly reduced after “binge” use of ethanol. Ethanol retarded suppression of cells by retroviral infection. However by 25 weeks of infection there was a 8.6% survival in the ethanol fed mice infected with retrovirus which was much less than virally infected controls (45.0%). Morphine treatment also increased the percentage of cells with markers for macrophages and activated macrophages in virally infected mice, while suppressing them in uninfected mice. The second and third morphine injection series suppressed lymphocyte T-helper and T-suppressor cells, but not total T cells. However, suppression by morphine was significantly less during retroviral disease than suppression caused by the virus only. At 25 weeks of infection 44.8% of morphine treated, infected mice survived. Morphine treatment also caused deaths such that the survival in morphine treated, retrovirally infected was higher than would have been expected if the death rate in virally infected, and morphine injected animals were combined during combined treatment. Thus these drugs of abuse can modulate peripheral blood lymphoid subsets, suppression caused by retroviral infection, and survival.
膳食视黄基棕榈酸酯和硒对肿瘤促进小鼠巨噬细胞杀肿瘤能力的影响。
影响因子：
9.7
作者：
Watson,RR;Moriguchi,S;Gensler,HL
通讯作者：
Gensler,HL
乙醇在细胞免疫系统中引起的功能和数值改变。
DOI：
10.1016/0162-3109(88)90055-0
发表时间：
1988
期刊：
Immunopharmacology
影响因子：
--
作者：
Mufti,SI;Prabhala,R;Moriguchi,S;Sipes,IG;Watson,RR
通讯作者：
Watson,RR