Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation.
Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation.
复制标题
新中国弥散性血管内凝血诊断评分系统的回顾性评价
DOI：
10.1371/journal.pone.0129170
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Wang M;Kou H;Deng J;Wang H;Guo T;Mei H;Hu Y
目的回顾性验证新的中国DIC评分系统（CDSS）。方法回顾性分析2013-4 ~ 2014-6在武汉协和医院住院的619例疑似DIC患者的临床资料，其中非恶性血液病371例，恶性血液病248例。我们通过与国际血栓与止血学会（ISTH）、日本急性医学会（JAAM）和日本厚生省（JMHW）的三个主要评分系统进行比较来验证CDSS，并通过28天死亡率、APACHE II和SOFA评分来评估其预后价值。结果在非血液系统恶性肿瘤中，CDSS的特异性高于JAAM（72.55% vs.50.49%，p<0.05），敏感性高于ISTH（77.07% vs.62.03%，p<0.05）。在恶性血液病中，CDSS的ROC曲线下面积大于ISTH和JMHW（ISTH为0.933 vs. 0.889，p<0.01，JMHW为0.944 vs. 0.845，p<0.01）。CDSS诊断的DIC患者28 d病死率、SOFA评分、APACHE II评分均显著高于非DIC患者（P <0.05）。结论我们是第一个提出CDSS的团体。强调了临床表现、血小板计数迅速下降、APTT对DIC的诊断价值，并以D-二聚体作为纤维蛋白相关指标。合并恶性血液病的DIC作为特殊部位治疗。CDSS对DIC的诊断具有一定的敏感性和特异性，对DIC患者的预后也有较好的预测价值。
Objectives To retrospectively validate the new Chinese DIC scoring system (CDSS). Methods This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International Society on Thrombosis and Haemostasis (ISTH), Japanese Association for Acute Medicine (JAAM) and Japanese Ministry of Health and Welfare (JMHW), and evaluated its prognostic value by 28 days mortality, APACHE II and SOFA score. Results In non-hematologic malignancies, CDSS was more specific than JAAM (72.55% vs. 50.49%, p<0.05) and more sensitive than ISTH (77.07% vs. 62.03%, p<0.05). In hematologic malignancies, the area under the ROC curve of CDSS was larger than ISTH and JMHW (0.933 vs. 0.889, p<0.01 with ISTH, 0.944 vs. 0.845, p<0.01 with JMHW). In addition, the 28-day mortality rate, SOFA scores, APACHE II scores of DIC patients diagnosed by CDSS were significantly greater than non-DIC (P <0.05). Conclusions We are the first group to propose CDSS. It emphasized the values of the clinical manifestations, the rapidly declining platelet count, APTT in the diagnosis of DIC and used D-dimer as the fibrin-related maker. DIC with hematological malignancies was treated as a special part. In this study we can see that CDSS displayed an acceptable property for the diagnosis of DIC with appropriate sensitivity and specificity, and also had a good prognostic value for DIC patients.
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影响因子：
8.8
作者：
Bakhtiari, K;Meijers, JCM;Levi, M
通讯作者：
Levi, M
影响因子：
120.7
作者：
RANGELFRAUSTO, MS;PITTET, D;WENZEL, RP
通讯作者：
WENZEL, RP
影响因子：
9.6
作者：
Dremsizov, T;Clermont, G;Angus, DC
通讯作者：
Angus, DC
影响因子：
5.7
作者：
Franchini, Massimo;Frattini, Francesco;Bonfanti, Carlo
通讯作者：
Bonfanti, Carlo
DOI：
10.1186/cc12783
发表时间：
2013-06-20
期刊：
Critical care (London, England)
影响因子：
--
作者：
Gando S;Saitoh D;Ogura H;Fujishima S;Mayumi T;Araki T;Ikeda H;Kotani J;Kushimoto S;Miki Y;Shiraishi S;Suzuki K;Suzuki Y;Takeyama N;Takuma K;Tsuruta R;Yamaguchi Y;Yamashita N;Aikawa N;Japanese Association for Acute Medicine Sepsis Registry Study Group
通讯作者：
Japanese Association for Acute Medicine Sepsis Registry Study Group