Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies.
Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies.
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DOI：
10.3389/fimmu.2021.705360
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发表时间：
2021
影响因子：
7.3
通讯作者：
Phogat S
中科院分区：
文献类型：
--
作者：
Clegg J;Soldaini E;McLoughlin RM;Rittenhouse S;Bagnoli F;Phogat S
金黄色葡萄球菌是世界范围内最重要的人类病原体之一。它的高抗生素耐药性特征加强了对新干预措施的需求，如除了新抗生素之外的疫苗。针对S.然而，这些人类临床和非临床研究的发现为这种失败提供了潜在的见解。目前，研究的重点是确定新的疫苗配方，能够引发有效的体液和细胞免疫反应。转化科学研究正试图使用动物模型以及评估候选疫苗功效的体外和离体模型来发现保护的相关性。几种新的候选疫苗正在各种目标人群中进行人体临床试验。除疫苗外，正在开发噬菌体、单克隆抗体、centyrin和新类别的抗生素。其中一些已经在人类身上进行了测试，结果令人鼓舞。疾病的复杂性和受此病原体影响的目标人群的范围将需要使用不同的干预措施，这将在本次审查中讨论多管齐下的方法。
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high antibiotic resistance profile reinforces the need for new interventions like vaccines in addition to new antibiotics. Vaccine development efforts against S. aureus have failed so far however, the findings from these human clinical and non-clinical studies provide potential insight for such failures. Currently, research is focusing on identifying novel vaccine formulations able to elicit potent humoral and cellular immune responses. Translational science studies are attempting to discover correlates of protection using animal models as well as in vitro and ex vivo models assessing efficacy of vaccine candidates. Several new vaccine candidates are being tested in human clinical trials in a variety of target populations. In addition to vaccines, bacteriophages, monoclonal antibodies, centyrins and new classes of antibiotics are being developed. Some of these have been tested in humans with encouraging results. The complexity of the diseases and the range of the target populations affected by this pathogen will require a multipronged approach using different interventions, which will be discussed in this review.
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影响因子：
4.4
作者：
Comoy, EE;Capron, A;Thyphronitis, G
通讯作者：
Thyphronitis, G
影响因子：
4.6
作者：
Flaxman A;van Diemen PM;Yamaguchi Y;Allen E;Lindemann C;Rollier CS;Milicic A;Wyllie DH
通讯作者：
Wyllie DH
影响因子：
3.1
作者：
BISTONI, F;VECCHIARELLI, A;CASSONE, A
通讯作者：
CASSONE, A
DOI：
10.1093/infdis/jiz692
发表时间：
2020-11-09
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Ciarlo E;Heinonen T;Théroude C;Asgari F;Le Roy D;Netea MG;Roger T
通讯作者：
Roger T
影响因子：
6.4
作者：
Boyle-Vavra, Susan;Li, Xue;Daum, Robert S.
通讯作者：
Daum, Robert S.