Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors.
Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors.
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DOI：
10.1371/journal.pone.0001216
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发表时间：
2007-11-21
期刊：
影响因子：
3.7
通讯作者：
Wilson DS
中科院分区：
文献类型：
--
作者：
Eisenberg DT;Campbell B;Mackillop J;Lum JK;Wilson DS
出生季节与许多生理和心理特征有关，包括新奇寻求和感觉寻求。类似的特征与多巴胺系统的遗传多态性有关。SOB和多巴胺受体遗传多态性可能通过对多巴胺能系统的共同影响独立且交互地影响类似的行为。基于195名受试者的样本，我们研究了性欲是否与冲动，感觉寻求和生殖行为有关。此外，我们还研究了多巴胺受体基因与同一组性状的多巴胺受体基因之间的潜在相互作用。使用社会性取向量表、Barratt冲动量表、Eysenck冲动问卷、感觉寻求量表和延迟折扣任务评估表型。受试者还被问及他们第一次性行为的年龄以及他们第一个孩子出生时的期望年龄。检测多巴胺受体D2（DRD 2）TaqIA和D4（DRD 4）48 bp VNTR基因多态性。主要分析包括每个依赖性状的析因性别×方差分析或二元逻辑回归模型。二次分析扩展了析因模型，还包括DRD 2和DRD 4基因型作为自变量。冬季出生的男性比非冬季出生的男性更寻求感觉。在以基因型和出生季节为变量的析因模型中，发现了两个以前未观察到的效应：（1）DRD 2 × DRD 4交互作用对冒险性的影响;（2）DRD 2 × DRD 4交互作用对感觉寻求的影响。这些结果与过去的研究结果一致，即情绪与感觉寻求有关。此外，这些结果提供了初步支持的假设，多巴胺能基因多态性的行为表达的修改。这些研究结果表明，在将来的危险行为研究和多巴胺系统的行为遗传学研究中，应该包括多巴胺。
Season of birth (SOB) has been associated with many physiological and psychological traits including novelty seeking and sensation seeking. Similar traits have been associated with genetic polymorphisms in the dopamine system. SOB and dopamine receptor genetic polymorphisms may independently and interactively influence similar behaviors through their common effects on the dopaminergic system. Based on a sample of 195 subjects, we examined whether SOB was associated with impulsivity, sensation seeking and reproductive behaviors. Additionally we examined potential interactions of dopamine receptor genes with SOB for the same set of traits. Phenotypes were evaluated using the Sociosexual Orientation Inventory, the Barratt Impulsivity Scale, the Eysenck Impulsivity Questionnaire, the Sensation Seeking Scale, and the Delay Discounting Task. Subjects were also asked about their age at first sex as well as their desired age at the birth of their first child. The dopamine gene polymorphisms examined were Dopamine Receptor D2 (DRD2) TaqI A and D4 (DRD4) 48 bp VNTR. Primary analyses included factorial gender×SOB ANOVAs or binary logistic regression models for each dependent trait. Secondary analysis extended the factorial models by also including DRD2 and DRD4 genotypes as independent variables. Winter-born males were more sensation seeking than non-winter born males. In factorial models including both genotype and season of birth as variables, two previously unobserved effects were discovered: (1) a SOB×DRD4 interaction effect on venturesomeness and (2) a DRD2×DRD4 interaction effect on sensation seeking. These results are consistent with past findings that SOB is related to sensation seeking. Additionally, these results provide tentative support for the hypothesis that SOB modifies the behavioral expression of dopaminergic genetic polymorphism. These findings suggest that SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system.
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影响因子：
3.2
作者：
Chotai, J;Forsgren, T;Adolfsson, R
通讯作者：
Adolfsson, R
影响因子：
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DOI：
10.1016/j.bbrc.2006.09.090
发表时间：
2006-11-24
影响因子：
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作者：
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通讯作者：
Kim, Kyeong-Man
影响因子：
2.7
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通讯作者：
Vernier, P