Relationships between blood rheology and age, body mass index, blood cell count, fibrinogen, and lipids in healthy subjects.
Relationships between blood rheology and age, body mass index, blood cell count, fibrinogen, and lipids in healthy subjects.
复制标题
健康受试者血液流变学与年龄、体重指数、血细胞计数、纤维蛋白原和血脂之间的关系。
DOI：
--
复制
发表时间：
2006
影响因子：
2.1
通讯作者：
M. Murakami
中科院分区：
文献类型：
--
作者：
Koji Seki;H. Sumino;M. Nara;N. Ishiyama;M. Nishino;M. Murakami
我们研究了健康受试者的微通道法测定的血液流变学与各种血液流变学因素之间的关系。176名健康志愿者（90名男性和86名女性，平均年龄; 32.9+/-11.3岁）参加了本研究。测量体重、体重指数、红细胞计数、红细胞压积、血红蛋白、白色细胞计数和血小板计数、血浆纤维蛋白原、空腹血脂和脂蛋白浓度。为了评估血液流变学，通过微通道方法（微通道阵列流动分析仪）测定血液通过时间。年龄、体重指数、红细胞计数、红细胞压积、血红蛋白、白色细胞计数、总胆固醇、低密度脂蛋白胆固醇和甘油三酯分别与所有受试者的血液通过时间呈正相关（p<0.01），高密度脂蛋白胆固醇与血液通过时间呈负相关（p<0.01）。血小板计数、纤维蛋白原与血液通过时间无相关性。目前的研究表明，年龄增加，体重指数，红细胞计数，白色血细胞计数，总胆固醇，低密度脂蛋白胆固醇，甘油三酯和降低高密度脂蛋白胆固醇与受损的血液流变学微通道法测量在健康受试者，提示衰老，肥胖，红细胞增多，白细胞增多，血脂异常可能与血液流变学疾病。这种微通道方法可能有助于研究血液流变学，这可能与各种危险因素的心血管疾病。
We investigated the relationships between blood rheology assessed by microchannel method and the various hemorheologic factors in healthy subjects. One hundred seventy-six healthy volunteers (90 men and 86 women, mean age; 32.9+/-11.3 years) were participated in this study. Body weight, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, and platelet count, plasma fibrinogen, and fasting serum lipid and lipoprotein concentrations were measured. In order to assess blood rheology, blood passage time was determined by a microchannel method (Micro Channel Array Flow Analyzer). Age, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride were positively correlated with blood passage time in all subjects, respectively (p<0.01) and high-density lipoprotein cholesterol was inversely correlated with blood passage time (p<0.01). However, platelet count, and fibrinogen were not correlated with blood passage time. The present study showed that increased age, body mass index, red blood cell count, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride and decreased high-density lipoprotein cholesterol were associated with impaired blood rheology measured by microchannel method in healthy subjects, suggesting that aging, obesity, erythrocytosis, leukocytosis, and dyslipidemia may be related to hemorheological disorders. This microchannel method may be useful to study blood rheology which may be associated with various risk factors of cardiovascular disorders.
影响因子：
5.3
作者：
SEPLOWITZ, AH;CHIEN, S;SMITH, FR
通讯作者：
SMITH, FR