Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.
Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.
复制标题
短杆菌肽 S 启发的抗菌环糊精可破坏革兰氏阴性和革兰氏阳性细菌膜。
DOI：
10.1039/c9md00229d
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Atsushi Miyagawa
中科院分区：
文献类型：
--
作者：
H. Yamamura;Kana Isshiki;Yusuke Fujita;Hisato Kato;T. Katsu;Kazufumi Masuda;Kayo Osawa;Atsushi Miyagawa
以环糊精为原料制备了具有膜活性的短杆菌肽S类两亲性结构。该模拟物是由6-氨基修饰的葡萄糖2，3-二-O-丙酸酯组成的环状低聚物，其对革兰氏阳性菌和革兰氏阴性菌具有抗菌活性，并且对红细胞没有耐药性发展和低溶血活性。
A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.
影响因子：
7.3
作者：
Mohammed I;Kummetha IR;Singh G;Sharova N;Lichinchi G;Dang J;Stevenson M;Rana TM
通讯作者：
Rana TM