Molecular cloning of lungfish proopiomelanocortin cDNA.
Molecular cloning of lungfish proopiomelanocortin cDNA.
复制标题
肺鱼阿黑皮质素原 cDNA 的分子克隆。
DOI:
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复制
发表时间:
1999
影响因子:
2.7
通讯作者:
H. Kawauchi
中科院分区:
文献类型:
--
作者:
Y. Amemiya;A. Takahashi;H. Meguro;H. Kawauchi
To investigate the evolution of proopiomelanocortin (POMC) from fish to tetrapods, nucleotide sequence of POMC cDNA from a lobe-finned fish, the African lungfish, was determined. POMC cDNA was prepared from lungfish pituitary glands. The POMC cDNA is composed of 1114 bp, excluding a poly-A tail, and encodes 255 amino acids (aa) including a signal peptide of 25 aa. The lungfish POMC contains the segment corresponding to gamma-melanotropin (MSH), corticotropin, alpha-MSH, beta-MSH, and beta-endorphin at positions (50-61), (108-146), (108-120), (178-194), and (197-230), respectively. The lungfish POMC shows greater sequence identity on average with amphibian (62%), ancient ray-finned fishes including acipenseriformes and semionotiformes (62%), and mammalian POMC (52%) than with teleostean (49%), elasmobranch (46%), and agnathan POMC (31%). Thus, the overall structural feature of lungfish POMC is close to the tetrapod POMCs which contain gamma-MSH and the ancient ray-finned fishes POMCs containing gamma-MSH-like sequence. However, amino acid sequence of lungfish beta-endorphin exhibits properties which are specifically observed in the ray-finned fishes and the elasmobranchs.
DOI:
10.1089/dna.1988.7.627
发表时间:
1988
期刊:
DNA (Mary Ann Liebert, Inc.)
影响因子:
--
作者:
Patel,PD;Sherman,TG;Watson,SJ
通讯作者:
Watson,SJ
DOI:
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发表时间:
1983
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Uhler,M;Herbert,E
通讯作者:
Herbert,E
影响因子:
2.7
作者:
Dores,RM;Adamczyk,DL;Joss,JM
通讯作者:
Joss,JM