Development of biomarkers to optimize pediatric patient management: what makes children different?

Development of biomarkers to optimize pediatric patient management: what makes children different?
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DOI:
10.2217/bmm.11.96
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发表时间:
2011-12
影响因子:
2.2
通讯作者:
Leeder JS
Leeder JS
中科院分区:
医学4区
文献类型:
--
作者:
Goldman J;Becker ML;Jones B;Clements M;Leeder JS

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尽管生物标志物在医疗实践中经常被使用,但关于经过验证的儿科生物标志物的信息相对缺乏。通常,发现对成人有效的生物标志物被外推到儿科临床环境,而没有考虑到许多疾病的发病机制在儿童中明显不同,个体发生直接影响儿童的疾病演变和治疗反应。新的和创新的方法是必要的,以提供可靠的,有效的生物标志物,可用于改善和推进儿科医疗保健。
Despite the frequent utilization of biomarkers in medical practice, there is a relative paucity of information regarding validated pediatric biomarkers. Frequently, biomarkers found to be efficacious in adults are extrapolated to the pediatric clinical setting without considering that the pathogenesis of many diseases is distinctly different in children, and ontogeny directly influences disease evolution and therapeutic response in children. New and innovative approaches are necessary to provide reliable, validated biomarkers that can be used to improve and advance pediatric medical care.
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