Agonist replacement therapy for cocaine dependence: a translational review.
Agonist replacement therapy for cocaine dependence: a translational review.
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DOI：
10.4155/fmc.11.184
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发表时间：
2012-02
影响因子：
4.2
通讯作者：
Stoops WW
中科院分区：
文献类型：
--
作者：
Rush CR;Stoops WW
Cocaine use disorders are prevalent throughout the world. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. This paper reviews the translational literature, including preclinical experiments, human laboratory studies and clinical trials, to determine whether agonist-replacement therapy is a viable strategy for managing cocaine dependence. Discussion is limited to transporter blockers (i.e., methylphenidate) and releasers (i.e., amphetamine analogs) that are available for use in humans in the hope of impacting clinical research and practice more quickly. The translational review suggests that agonist-replacement therapy, especially monoamine releasers, may be effective for managing cocaine dependence. Future directions for medications development are also discussed because the viability of agonist-replacement therapy for cocaine dependence may hinge on identifying novel compounds or formulations that have less abuse and diversion potential.
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影响因子：
3.4
作者：
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通讯作者：
Howell, Leonard L.
影响因子：
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作者：
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影响因子：
4.1
作者：
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通讯作者：
Bramble, D
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通讯作者：
Howar, JL
影响因子：
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作者：
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通讯作者：
Preston, KL