Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health.
Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health.
复制标题
了解超长链多不饱和脂肪酸（VLC-PUFA）在眼睛健康中的作用。
DOI：
10.3390/nu15143096
复制
发表时间：
2023-07-10
期刊：
影响因子：
5.9
通讯作者：
Bernstein, Paul S.
中科院分区：
文献类型：
--
作者：
Nwagbo, Uzoamaka;Bernstein, Paul S.
关键词：
Lipids serve many roles in the neural system, from synaptic stabilization and signaling to DNA regulation and neuroprotection. They also regulate inflammatory responses, maintain cellular membrane structure, and regulate the homeostatic balance of ions and signaling molecules. An imbalance of lipid subgroups is implicated in the progression of many retinal diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, and diabetic retinopathy, and diet can play a key role in influencing these diseases’ onset, progression, and severity. A special class of lipids termed very-long-chain polyunsaturated fatty acids (VLC-PUFAs) is found exclusively in mammalian vertebrate retinas and a few other tissues. They comprise <2% of fatty acids in the retina and are depleted in the retinas of patients with diseases like diabetic retinopathy and AMD. However, the implications of the reduction in VLC-PUFA levels are poorly understood. Dietary supplementation studies and ELOVL4 transgene studies have had positive outcomes. However, much remains to be understood about their role in retinal health and the potential for targeted therapies against retinal disease.
登录
查看更多内容
影响因子：
6
作者：
Dasyani M;Gao F;Xu Q;Van Fossan D;Zhang E;F M Pinto A;Saghatelian A;Skowronska-Krawczyk D;Chao DL
通讯作者：
Chao DL
营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
影响因子：
2.9
作者：
AVELDANO, MI
通讯作者：
AVELDANO, MI
影响因子：
2.1
作者：
Berdeaux, Olivier;Acar, Niyazi
通讯作者：
Acar, Niyazi
影响因子：
4.4
作者：
Donato，Luigi;Scimone，Concetta;Sidoti，Antonina
通讯作者：
Sidoti，Antonina