Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.
Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases.
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营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
DOI：
10.1146/annurev.nutr.012809.104635
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发表时间：
2011-08-21
影响因子：
8.9
通讯作者：
Gordon WC
中科院分区：
文献类型：
--
作者：
Bazan NG;Molina MF;Gordon WC
必需多不饱和脂肪酸(PUFAs)是维持体内平衡的关键营养脂质，必须从饮食中获得。Omega-3和-6多不饱和脂肪酸是生物膜的关键成分，在细胞的完整性、发育、维持和功能方面发挥着重要作用。必需的omega-3脂肪酸家族成员二十二碳六烯酸(DHA)在神经系统，特别是光感受器和突触膜中被大量保留和唯一地集中。DHA在视觉、神经保护、成功衰老、记忆和其他功能中起着关键作用。此外，与omega-6多不饱和脂肪酸家族的几个成员的促炎作用相比，DHA显示出抗炎和消炎特性。本文综述了DHA信号脂质组学，包括DHA摄取的细胞/组织组织，DHA在细胞间的分布，富含DHA磷脂的膜区的组织和功能，以及DHA和二十二碳二烯调节的信号通路的发现所揭示的细胞和分子事件，DHA和二十二碳二烯类化合物是DHA衍生的生物活性脂类，包括神经保护素D1(NPD1)，一种新的DHA衍生的立体选择性介体。NPD1的合成激动剂包括神经营养素和氧化应激；NPD1具有强大的抗炎作用和动态平衡活性，具有抗血管生成、促进角膜神经再生和诱导细胞存活的作用。在DHA信号脂组学的背景下，该综述重点介绍了衰老以及DHA在阿尔茨海默病、黄斑变性、帕金森病和其他大脑疾病中的重要性的研究进展。神经系统中的DHA信号脂组学为药物干预和临床翻译提供了新的靶点。
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis. Omega-3 and -6 PUFAs are key components of biomembranes and play important roles in cell integrity, development, maintenance, and function. The essential omega-3 fatty acid family member docosahexaenoic acid (DHA) is avidly retained and uniquely concentrated in the nervous system, particularly in photoreceptors and synaptic membranes. DHA plays a key role in vision, neuroprotection, successful aging, memory, and other functions. In addition, DHA displays anti-inflammatory and inflammatory resolving properties in contrast to the proinflammatory actions of several members of the omega-6 PUFAs family. This review discusses DHA signalolipidomics, comprising the cellular/tissue organization of DHA uptake, its distribution among cellular compartments, the organization and function of membrane domains rich in DHA-containing phospholipids, and the cellular and molecular events revealed by the uncovering of signaling pathways regulated by DHA and docosanoids, the DHA-derived bioactive lipids, which include neuroprotectin D1 (NPD1), a novel DHA-derived stereoselective mediator. NPD1 synthesis agonists include neurotrophins and oxidative stress; NPD1 elicits potent anti-inflammatory actions and prohomeostatic bioactivity, is anti-angiogenic, promotes corneal nerve regeneration, and induces cell survival. In the context of DHA signalolipidomics, this review highlights aging and the evolving studies on the significance of DHA in Alzheimer’s disease, macular degeneration, Parkinson’s disease, and other brain disorders. DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation.
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影响因子：
3.7
作者：
Astarita G;Jung KM;Berchtold NC;Nguyen VQ;Gillen DL;Head E;Cotman CW;Piomelli D
通讯作者：
Piomelli D
影响因子：
2.9
作者：
AVELDANO, MI
通讯作者：
AVELDANO, MI
DOI：
10.1097/01.mpg.0000338811.52062.b2
发表时间：
2008-11-01
影响因子：
2.9
作者：
Agostoni, Carlo
通讯作者：
Agostoni, Carlo
DOI：
10.1016/0006-291x(84)90601-6
发表时间：
1984-01-01
影响因子：
3.1
作者：
BAZAN, NG;BIRKLE, DL;REDDY, TS
通讯作者：
REDDY, TS
DOI：
10.1016/0006-291x(72)90403-2
发表时间：
1972-01-01
影响因子：
3.1
作者：
AVELDANO, MI;BAZAN, NG
通讯作者：
BAZAN, NG