Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes.
Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes.
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作者：
为了评估美国 2 型糖尿病 (T2D) 患者严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染以及感染严重程度与长期血糖控制和体重之间的关系，我们利用国家新冠肺炎队列协作组织 (N3C) 的 SARS-CoV-2 感染患者的纵向电子健康记录数据进行了一项回顾性队列研究。患者年龄≥18岁，经 ICD-10 诊断为 T2D，并且在首次 2019 年冠状病毒病 (COVID-19) 诊断或 SARS-CoV-2 检测阴性的索引日期之前和之后至少进行一次 HbA1c 和体重测量。我们使用倾向评分来确定在人口特征、合并症和用于治疗糖尿病的药物方面平衡的匹配队列。主要结果是感染和未感染 SARS-CoV-2 的患者从索引日期后 90 天开始的 1 年内的索引后平均 HbA1c 和索引后平均体重。次要结局是需要住院或机械通气的患者的术后平均 HbA1c 和体重。与对照组相比，SARS-CoV-2 感染患者的术后平均 HbA1c 或体重没有显着差异。 COVID-19 后机械通气与平均 HbA1c 下降相关。在美国先前患有 T2D 患者的多中心队列中，患有 COVID-19 的患者的长期平均 HbA1c 或体重没有显着变化。 COVID-19 后机械通气与 HbA1c 下降相关。
To evaluate the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity of infection with longer-term glycemic control and weight in people with type 2 diabetes (T2D) in the U.S. We conducted a retrospective cohort study using longitudinal electronic health record data of patients with SARS-CoV-2 infection from the National COVID Cohort Collaborative (N3C). Patients were ≥18 years old with an ICD-10 diagnosis of T2D and at least one HbA1c and weight measurement prior to and after an index date of their first coronavirus disease 2019 (COVID-19) diagnosis or negative SARS-CoV-2 test. We used propensity scores to identify a matched cohort balanced on demographic characteristics, comorbidities, and medications used to treat diabetes. The primary outcome was the postindex average HbA1c and postindex average weight over a 1 year time period beginning 90 days after the index date among patients who did and did not have SARS-CoV-2 infection. Secondary outcomes were postindex average HbA1c and weight in patients who required hospitalization or mechanical ventilation. There was no significant difference in the postindex average HbA1c or weight in patients who had SARS-CoV-2 infection compared with control subjects. Mechanical ventilation was associated with a decrease in average HbA1c after COVID-19. In a multicenter cohort of patients in the U.S. with preexisting T2D, there was no significant change in longer-term average HbA1c or weight among patients who had COVID-19. Mechanical ventilation was associated with a decrease in HbA1c after COVID-19.
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DOI：
10.1210/clinem/dgab792
发表时间：
2022-02-17
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Laurenzi A;Caretto A;Molinari C;Mercalli A;Melzi R;Nano R;Tresoldi C;Rovere Querini P;Ciceri F;Lampasona V;Bosi E;Scavini M;Piemonti L
通讯作者：
Piemonti L
影响因子：
5.7
作者：
Raghavan, Sridharan;Liu, Wenhui G.;Caplan, Liron
通讯作者：
Caplan, Liron
影响因子：
1.9
作者：
Rosenbaum, Paul R.
通讯作者：
Rosenbaum, Paul R.
影响因子：
3.7
作者：
Rozing, Maarten P.;Moller, Anne;Koster-Rasmussen, Rasmus
通讯作者：
Koster-Rasmussen, Rasmus
影响因子：
3.7
作者：
Biamonte E;Pegoraro F;Carrone F;Facchi I;Favacchio G;Lania AG;Mazziotti G;Mirani M
通讯作者：
Mirani M