Weight change and glycemic control in type 2 diabetes patients during COVID-19 pandemic: the lockdown effect.
Weight change and glycemic control in type 2 diabetes patients during COVID-19 pandemic: the lockdown effect.
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DOI：
10.1007/s12020-021-02739-5
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发表时间：
2021-06
期刊：
影响因子：
3.7
通讯作者：
Mirani M
中科院分区：
文献类型：
--
作者：
Biamonte E;Pegoraro F;Carrone F;Facchi I;Favacchio G;Lania AG;Mazziotti G;Mirani M
本研究旨在评估2020年3月9日至5月18日在意大利发生的COVID-19封锁对2型糖尿病（T2DM）患者人体测量参数和血糖控制的影响。在封锁期结束时对128例连续T2DM患者（中位年龄70岁，74例男性）进行回顾性评估。在不同时间收集代谢控制数据：封锁前三个月内（第0次访问）和封锁后的前六周内（第1次访问）。在封锁期间,体重显著增加(从79.7±18.7公斤到81.4±19.4公斤,p < 0.001),身体质量指数(BMI,从29.5±6 kg / m2 30.1±6.3 kg / m2, p < 0.001),腰围(从103.8±13厘米105±13.6厘米,p < 0.001),空腹血糖(台塑;从138.1±29.4 mg / dL 146.6±36.4 mg / dL)和糖化血红蛋白(糖化血红蛋白;从7±0.8到7.3±0.9%,p < 0.001)被观察到。体重增加与HbA1c升高直接相关（β 0.085， C.I. 95% 0.05-0.121; p < 0.001），而胰岛素治疗是多因素logistic回归分析中唯一显著的HbA1c恶化独立预测因子（OR 2.40， C.I. 1.06-5.45; p = 0.035）。COVID-19大流行导致的封锁对2型糖尿病患者的体重和血糖控制产生了负面影响，特别是对那些接受胰岛素治疗的患者。这一发现为优化居家坐月子期间的糖尿病管理提供了进一步的理论依据。
The aim of this study was to evaluate the impact of the COVID-19 lockdown occurred in Italy from March 9th to May 18th, 2020 on anthropometric parameters and glycemic control in patients with type 2 diabetes mellitus (T2DM). One hundred twenty-eight consecutive patients with T2DM (median age 70 years, 74 males) were retrospectively evaluated at the end of the lockdown period. Data on metabolic control were collected at different time: within three months before the lockdown (visit 0) and within the first six weeks after it (visit 1). During the lockdown, a significant increase in body weight (from 79.7 ± 18.7 kg to 81.4 ± 19.4 kg, p < 0.001), body mass index (BMI, from 29.5 ± 6 kg/m2 to 30.1 ± 6.3 kg/m2, p < 0.001), waist circumference (from 103.8 ± 13 cm to 105 ± 13.6 cm, p < 0.001), fasting plasma glucose (FPG; from 138.1 ± 29.4 mg/dL to 146.6 ± 36.4 mg/dL) and glycated hemoglobin (HbA1c; from 7 ± 0.8 to 7.3 ± 0.9%, p < 0.001) was observed. Weight gain was directly associated with HbA1c increase (β 0.085, C.I. 95% 0.05–0.121; p < 0.001) while insulin therapy resulted to be the only significant independent predictor of HbA1c worsening at the multivariate logistic regression analysis (OR 2.40, C.I. 1.06–5.45; p = 0.035). The lockdown due to COVID-19 pandemic had a negative impact on body weight and glucose control in T2DM patients, in particular in those on insulin treatment. This finding provides a further rationale to optimize the diabetes management during eventually new period of home confinement.
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影响因子：
5.1
作者：
Rechenberg K;Whittemore R;Holland M;Grey M
通讯作者：
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影响因子：
1.4
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DOI：
10.1016/j.dsx.2020.07.016
发表时间：
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影响因子：
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