The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease.
The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease.
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DOI：
10.3389/fphar.2020.603104
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发表时间：
2020
影响因子：
5.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Liu J;Wu J;Li L;Li T;Wang J
心血管疾病(CVD)仍然是全球发病率和死亡率的主要原因。动脉粥样硬化(AS)是心血管疾病的主要原因。氧化应激、内皮功能障碍和炎症是AS发生发展的关键因素。胞外体是大多数类型的细胞分泌到细胞外空间的纳米级囊泡，是细胞间信号传递和整合的理想物质。细胞可以选择性地将脂类、蛋白质和RNA等生物活性物质包裹在外体中，并通过旁分泌机制发挥作用。非编码RNA(NcRNAs)对于细胞间的通讯非常重要。它们可以通过外切体到达受体细胞，引起表型变化，并在细胞功能中发挥分子调节作用。阐明它们的分子机制有助于确定CVD的治疗靶点或策略。冠心病(CAD)是心血管疾病中最重要的疾病。在这里，我们综述了外体ncRNA在冠心病病理生理中的作用和调节机制，以及外体ncRNA在冠心病诊断和治疗中的潜在贡献。
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Atherosclerosis (AS) is a major cause of CVD. Oxidative stress, endothelial dysfunction, and inflammation are key factors involved in the development and progression of AS. Exosomes are nano-sized vesicles secreted into the extracellular space by most types of cells, and are ideal substances for the transmission and integration of signals between cells. Cells can selectively encapsulate biologically active substances, such as lipids, proteins and RNA in exosomes and act through paracrine mechanisms. Non-coding RNAs (ncRNAs) are important for communication between cells. They can reach the recipient cells through exosomes, causing phenotypic changes and playing a molecular regulatory role in cell function. Elucidating their molecular mechanisms can help identify therapeutic targets or strategies for CVD. Coronary artery disease (CAD) is the most important disease in CVD. Here, we review the role and the regulatory mechanism of exosomal ncRNAs in the pathophysiology of CAD, as well as the potential contribution of exosomal ncRNA to diagnosis and treatment of CAD.
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