Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies.
Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies.
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DOI：
10.3390/ncrna3010010
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发表时间：
2017-02-23
期刊：
影响因子：
4.3
通讯作者：
Nawaz M
中科院分区：
文献类型：
--
作者：
Fatima F;Nawaz M
细胞外小泡(EV)是几乎所有细胞类型分泌的纳米大小的小泡，被认为在细胞之间运输蛋白质、脂类和核酸，包括非编码RNA(NcRNAs)。因为，在发育过程中，ncRNAs是转录调控的中心；真核生物可能通过在细胞之间转位ncRNAs而进化出新的转录后调控手段。EV介导的调节元件的运输为细胞间的反式调节提供了一个新的来源。在过去的十年中，研究主要集中在microRNAs上，而对长ncRNA(LncRNA)功能的研究则要少得多。在这里，我们回顾了与EV相关的ncRNAs的调节作用，特别关注lncRNAs，它们如何在受体细胞中促进转录调节的口述模式。这指的是设想在受体细胞中引发表观遗传调节、细胞重编程和基因组不稳定的新机制，最终允许产生启动癌症的细胞表型、衰老和对化疗的耐药性。相反，这种反式调节可能会在受体癌细胞中引入RNA干扰，导致癌基因和抗凋亡蛋白的抑制，从而有利于肿瘤抑制。总之，了解这些机制对于通过在癌细胞内进行基因操作而实现的基于EV的RNA治疗具有重要价值，而来自癌症患者的EV的ncRNA含量可以作为治疗反应的诊断生物标志物和预后指标的非侵入性来源。
Extracellular vesicles (EVs) are nanosized vesicles secreted from virtually all cell types and are thought to transport proteins, lipids and nucleic acids including non-coding RNAs (ncRNAs) between cells. Since, ncRNAs are central to transcriptional regulation during developmental processes; eukaryotes might have evolved novel means of post-transcriptional regulation by trans-locating ncRNAs between cells. EV-mediated transportation of regulatory elements provides a novel source of trans-regulation between cells. In the last decade, studies were mainly focused on microRNAs; however, functions of long ncRNA (lncRNA) have been much less studied. Here, we review the regulatory roles of EV-linked ncRNAs, placing a particular focus on lncRNAs, how they can foster dictated patterns of trans-regulation in recipient cells. This refers to envisaging novel mechanisms of epigenetic regulation, cellular reprogramming and genomic instability elicited in recipient cells, ultimately permitting the generation of cancer initiating cell phenotypes, senescence and resistance to chemotherapies. Conversely, such trans-regulation may introduce RNA interference in recipient cancer cells causing the suppression of oncogenes and anti-apoptotic proteins; thus favoring tumor inhibition. Collectively, understanding these mechanisms could be of great value to EV-based RNA therapeutics achieved through gene manipulation within cancer cells, whereas the ncRNA content of EVs from cancer patients could serve as non-invasive source of diagnostic biomarkers and prognostic indicators in response to therapies.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
来自耐药乳腺癌细胞的外泌体通过 MicroRNA 的水平转移传递化疗耐药性
影响因子：
3.7
作者：
Chen WX;Liu XM;Lv MM;Chen L;Zhao JH;Zhong SL;Ji MH;Hu Q;Luo Z;Wu JZ;Tang JH
通讯作者：
Tang JH
影响因子：
4.1
作者：
Conley A;Minciacchi VR;Lee DH;Knudsen BS;Karlan BY;Citrigno L;Viglietto G;Tewari M;Freeman MR;Demichelis F;Di Vizio D
通讯作者：
Di Vizio D
影响因子：
--
作者：
Amicone L;Citarella F;Cicchini C
通讯作者：
Cicchini C
人类结肠癌细胞分泌的外泌体会影响邻近转移细胞的粘附：microRNA-210的作用。
影响因子：
3.6
作者：
Bigagli E;Luceri C;Guasti D;Cinci L
通讯作者：
Cinci L