Elucidating the genetic basis of social interaction and isolation.
Elucidating the genetic basis of social interaction and isolation.
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DOI：
10.1038/s41467-018-04930-1
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发表时间：
2018-07-03
影响因子：
16.6
通讯作者：
Perry JRB
中科院分区：
文献类型：
--
作者：
Day FR;Ong KK;Perry JRB
社会孤立和孤独对健康的负面影响有充分的证据。然而，人们对其可能的生物学决定因素知之甚少。在多达452，302名英国生物银行研究参与者中，我们对孤独感和定期参与社交活动进行了全基因组关联研究分析。我们确定了15个孤独的基因组位点（P < 5 × 10−8），并证明肥胖与孤独和抑郁症状易感性增加之间可能存在因果关系。另外的基因座被鉴定为经常参加体育俱乐部或健身房（N = 6个基因座）、酒吧或社交俱乐部（N = 13）或宗教团体（N = 18）。在这些特征中，控制情绪表达和行为的大脑区域中表达的基因非常丰富。我们证明了每个性状的病因机制，除了确定基因座是多效性的多个复杂的性状。对这些特征的进一步研究可能会发现与社交退缩和孤立相关的新的可改变的风险因素。尽管社会孤立和孤独对健康的重要性已得到公认，但人们对社会孤立和孤独的遗传决定因素知之甚少。在这里，使用多性状GWAS，Day等人确定了15个孤独的基因组位点，并通过MR进一步显示了BMI和孤独之间的双向因果关系。
The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10−8) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and depressive symptoms. Further loci were identified for regular attendance at a sports club or gym (N = 6 loci), pub or social club (N = 13) or religious group (N = 18). Across these traits there was strong enrichment for genes expressed in brain regions that control emotional expression and behaviour. We demonstrate aetiological mechanisms specific to each trait, in addition to identifying loci that are pleiotropic across multiple complex traits. Further study of these traits may identify novel modifiable risk factors associated with social withdrawal and isolation. Little is known about the genetic determinants of social isolation and loneliness despite their well-established importance for health. Here, using multi-trait GWAS, Day et al. identify 15 genomic loci for loneliness and further show a bidirectional causal relationship between BMI and loneliness by MR.
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影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
30.8
作者：
Finucane HK;Bulik-Sullivan B;Gusev A;Trynka G;Reshef Y;Loh PR;Anttila V;Xu H;Zang C;Farh K;Ripke S;Day FR;ReproGen Consortium;Schizophrenia Working Group of the Psychiatric Genomics Consortium;RACI Consortium;Purcell S;Stahl E;Lindstrom S;Perry JR;Okada Y;Raychaudhuri S;Daly MJ;Patterson N;Neale BM;Price AL
通讯作者：
Price AL
影响因子：
30.8
作者：
Finucane HK;Reshef YA;Anttila V;Slowikowski K;Gusev A;Byrnes A;Gazal S;Loh PR;Lareau C;Shoresh N;Genovese G;Saunders A;Macosko E;Pollack S;Brainstorm Consortium;Perry JRB;Buenrostro JD;Bernstein BE;Raychaudhuri S;McCarroll S;Neale BM;Price AL
通讯作者：
Price AL
影响因子：
30.8
作者：
Loh, Po-Ru;Tucker, George;Bulik-Sullivan, Brendan K.;Vilhjalmsson, Bjarni J.;Finucane, Hilary K.;Salem, Rany M.;Chasman, Daniel I.;Ridker, Paul M.;Neale, Benjamin M.;Berger, Bonnie;Patterson, Nick;Price, Alkes L.
通讯作者：
Price, Alkes L.
影响因子：
12.6
作者：
Holt-Lunstad, Julianne;Smith, Timothy B.;Stephenson, David
通讯作者：
Stephenson, David