Molecular control of facial morphology.
Molecular control of facial morphology.
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DOI：
10.1016/j.semcdb.2009.09.002
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发表时间：
2010-05
影响因子：
7.3
通讯作者：
Helms JA
中科院分区：
文献类型：
--
作者：
Liu B;Rooker SM;Helms JA
We present a developmental perspective on the concept of phylotypic and phenotypic stages of craniofacial development. Within Orders of avians and mammals, a phylotypic period exists when the morphology of the facial prominences is minimally divergent. We postulate that species-specific facial variations arise as a result of subtle shifts in the timing and the duration of molecular pathway activity (e.g., heterochrony), and present evidence demonstrating a critical role for Wnt and FGF signaling in this process. The same molecular pathways that shape the vertebrate face are also implicated in craniofacial deformities, indicating that comparisons between and among animal species may represent a novel method for the identification of human craniofacial disease genes.
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