Dynamics of cortical contrast adaptation predict perception of signals in noise.
Dynamics of cortical contrast adaptation predict perception of signals in noise.
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DOI：
10.1038/s41467-023-40477-6
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发表时间：
2023-08-09
影响因子：
16.6
通讯作者：
Geffen, Maria N.
中科院分区：
文献类型：
--
作者：
Angeloni, Christopher F.;Mlynarski, Wiktor;Piasini, Eugenio;Williams, Aaron M.;Wood, Katherine C.;Garami, Linda;Hermundstad, Ann M.;Geffen, Maria N.
整个感觉通路的神经元根据感觉环境的统计结构调整它们的反应。对比增益控制是听觉皮层中的一种适应形式，但目前尚不清楚增益控制的动态是否反映了有效的适应，以及它们是否塑造了行为感知。在这里，我们训练老鼠在背景对比度改变后不久检测在背景噪声中出现的目标。观察到的皮质增益和行为检测的变化遵循有效对比度增益控制的规范模型的动态；具体来说，在低对比度下，目标检测和灵敏度提高缓慢，而在高对比度下，目标检测和灵敏度下降迅速。这项任务需要听觉皮层，而且皮层反应不仅受到对比的相似影响，而且预测了行为表现的可变性。综上所述，我们的研究结果表明，动态增益适应支持听觉皮层的有效编码，并预测噪声中的声音感知。听觉系统会适应到达耳朵的声音的特性，但这是否会影响声音的感知方式尚不清楚。在这里，作者发现大脑中的听觉反应预测了声音感知的变化，这表明适应塑造了我们的听觉方式。
Neurons throughout the sensory pathway adapt their responses depending on the statistical structure of the sensory environment. Contrast gain control is a form of adaptation in the auditory cortex, but it is unclear whether the dynamics of gain control reflect efficient adaptation, and whether they shape behavioral perception. Here, we trained mice to detect a target presented in background noise shortly after a change in the contrast of the background. The observed changes in cortical gain and behavioral detection followed the dynamics of a normative model of efficient contrast gain control; specifically, target detection and sensitivity improved slowly in low contrast, but degraded rapidly in high contrast. Auditory cortex was required for this task, and cortical responses were not only similarly affected by contrast but predicted variability in behavioral performance. Combined, our results demonstrate that dynamic gain adaptation supports efficient coding in auditory cortex and predicts the perception of sounds in noise. The auditory system adapts to properties of sounds reaching the ear, but it is unclear whether this affects the way sounds are perceived. Here, the authors found that auditory responses in the brain predict changes in the perception of sounds, suggesting that adaptation shapes the way we hear.
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影响因子：
5.4
作者：
ATTNEAVE, F
通讯作者：
ATTNEAVE, F
影响因子：
16.2
作者：
Atallah BV;Bruns W;Carandini M;Scanziani M
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Scanziani M
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Bharioke A;Chklovskii DB
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