Role of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy.
Role of epigenetics in cellular reprogramming; from iPSCs to disease modeling and cell therapy.
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DOI：
10.1002/jcb.30164
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发表时间：
2022-03
影响因子：
4
通讯作者：
Darabi R
中科院分区：
文献类型：
--
作者：
Li Y;Darabi R
表观遗传学在IPSC技术中起着基础性的作用，因为它们影响IPSC的重新编程效率，并随后在IPSC向特定谱系分化的过程中发挥作用。表观遗传学可以基于源细胞的表观遗传记忆将iPSCs的分化过程向特定的谱系倾斜，甚至由于其在重新编程过程中的异常而导致获得新的细胞表型。这一观点讨论了IPSC重新编程/分化过程中表观遗传过程的关键特征，并概述了成功产生和分化用于下游应用的IPSC需要考虑的重要表观遗传因素。
Epigenetics play a fundamental role in iPSC technology due to their effect on iPSC’s reprogramming efficiency and their subsequent role in iPSC differentiation toward a specific lineage. Epigenetics can skew the differentiation course of iPSCs toward a specific lineage based on the epigenetic memory of the source cells, or even lead to acquisition of new cell phenotypes, due to its aberrations during reprogramming. This viewpoint discusses key features of the epigenetic process during iPSC reprogramming/differentiation and outlines important epigenetic factors that need to be considered for successful generation and differentiation of iPSCs for downstream applications.
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