The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.
The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review.
复制标题
DOI：
10.3389/fendo.2022.868441
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖和心血管疾病是全球主要的公共卫生问题。母亲肥胖与母亲和婴儿的多种不良健康后果有关。怀孕期间的肥胖可能会对宫内环境产生不利影响，据推测，这会使后代一生中心血管健康状况较差。在本文中，我们系统地回顾了当前研究母亲肥胖与后代心血管健康之间联系的文献。本研究已在 PROSPERO 注册 (CRD42021278567)，并按照 PRISMA 指南进行。进行了全面系统的文献检索，包括两个电子数据库（Ovid Medline、Embase）、交叉引用、作者检索和灰色文献检索。我们使用预先定义的资格标准选择了探索母亲肥胖与后代心血管健康之间关系的研究。使用 ROBINS-I 工具对研究进行了严格评价。从 1,214 条结果中，有 27 篇文章符合资格标准。考虑了多种心血管结局，包括先天性心脏病、心脏代谢参数以及新生儿、儿童和成人的心血管疾病。在这些研究中，母亲肥胖始终与先天性心脏病、一生中一些不利的心脏代谢参数有关，包括较高的体重指数和胰岛素水平，以及成年后患心血管疾病的风险较高。假设的潜在机制是复杂且多因素的，包括遗传、环境和社会经济成分，很难量化。研究设计的异质性、精心挑选的研究样本以及某些研究中的高偏倚风险限制了有关因果关系的结论。我们发现了一致的证据，证明母亲肥胖与后代心血管健康状况较差之间存在联系，贯穿从新生儿期到成年期的整个生命周期。尽管潜在机制尚不清楚，但我们的研究结果支持考虑有针对性地预防孕产妇肥胖，以促进后代心血管健康。这项包罗万象的系统评价对最新证据进行了批判性评估，明确了现有文献的差距和偏见，并可能为心血管疾病预防的潜在新公共卫生策略提供信息。 []，标识符 PROSPERO (CRD42021278567)。
Obesity and cardiovascular disease are major global public health problems. Maternal obesity has been linked to multiple adverse health consequences for both mother and baby. Obesity during pregnancy may adversely alter the intrauterine environment, which has been hypothesised to predispose the offspring to poorer cardiovascular health throughout life. In this paper, we systematically review current literature examining the links between maternal obesity and offspring cardiovascular health. This study is registered with PROSPERO (CRD42021278567) and was conducted in accordance with the PRISMA guidelines. A comprehensive systematic literature search was conducted, including two electronic databases (Ovid Medline, Embase), cross-referencing, author searching, and grey literature searches. We selected studies exploring the relationship between maternal obesity and offspring cardiovascular health, using pre-defined eligibility criteria. Studies were critically appraised using the ROBINS-I tool. From 1,214 results, 27 articles met the eligibility criteria. Multiple cardiovascular outcomes were considered, including congenital heart disease, cardiometabolic parameters, and cardiovascular diseases in neonates, children, and adults. In these studies, maternal obesity was consistently associated with congenital heart disease, several adverse cardiometabolic parameters throughout life including higher body mass index and insulin levels, and greater risk of cardiovascular disease in adulthood. Hypothesized underlying mechanisms are complex and multifactorial comprising genetic, environmental, and socioeconomic components, which can be difficult to quantify. Heterogeneity in study designs, highly selected study samples, and high risk of bias in some studies limit conclusions regarding causality. We identified consistent evidence of links between maternal obesity and poorer offspring cardiovascular health throughout the lifecourse, extending from the neonatal period into adulthood. Although underlying mechanisms are unclear, our findings support consideration of targeted maternal obesity prevention for promotion of offspring cardiovascular health. This all-encompassing systematic review provides critical appraisal of the latest evidence, defines gaps and biases of existing literature, and may inform potential new public health strategies for cardiovascular disease prevention. [], identifier PROSPERO (CRD42021278567).
DOI：
10.1038/ijo.2017.109
发表时间：
2017-09
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Wang H;Xu BP;Xu RB;Walker SO;Wang G
通讯作者：
Wang G
影响因子：
6.9
作者：
Lawrence, Gabriella M.;Shulman, Shani;Friedlander, Yechiel;Sitlani, Colleen M.;Burger, Ayala;Savitsky, Bella;Granot-Hershkovitz, Einat;Lumley, Thomas;Kwok, Pui-Yan;Hesselson, Stephanie;Enquobahrie, Daniel;Wander, Pandora L.;Manor, Orly;Siscovick, David S.;Hochner, Hagit
通讯作者：
Hochner, Hagit