Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI.
Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI.
复制标题
DOI：
10.1002/oby.20643
复制
发表时间：
2014-04
期刊：
影响因子：
6.9
通讯作者：
Hochner, Hagit
中科院分区：
文献类型：
--
作者：
Lawrence, Gabriella M.;Shulman, Shani;Friedlander, Yechiel;Sitlani, Colleen M.;Burger, Ayala;Savitsky, Bella;Granot-Hershkovitz, Einat;Lumley, Thomas;Kwok, Pui-Yan;Hesselson, Stephanie;Enquobahrie, Daniel;Wander, Pandora L.;Manor, Orly;Siscovick, David S.;Hochner, Hagit
研究表明肥胖相关表型的变化与心血管风险之间存在关联。虽然母亲孕前BMI（mppBMI）和妊娠期体重增加（GWG）可能与成年后代肥胖有关，但没有研究检查与肥胖变化的相关性。我们研究了mppBMI和GWG与后代BMI纵向变化（ΔBMI）的关系，并评估了这种关系是否可以通过后代遗传学来解释。我们使用了1400名成年人的出生队列，包括出生时、17岁和32岁的数据。在对后代进行基因分型后，我们创建了遗传评分，预测暴露和结果，并拟合线性回归模型，以检查mppBMI和GWG与ΔBMI的相关性。mppBMI和GWG的一个SD变化分别与ΔBMI增加0.83和0.75 kg/m2相关。mppBMI和后代ΔBMI之间的关联随着遗传评分的增加而略有减弱（12%）。在GWG模型中，观察到系数显著降低28.2%。这项研究指出，母亲在怀孕期间超重和后代从青春期到成年的BMI变化之间存在关联。遗传因素可能是GWG/ΔBMI相关性的部分原因。这些发现拓宽了观察，母亲肥胖相关的表型对后代的健康有长期的后果。
Studies demonstrate associations between changes in obesity-related phenotypes and cardiovascular risk. While maternal pre-pregnancy BMI (mppBMI) and gestational weight gain (GWG) may be associated with adult offspring adiposity, no study has examined associations with obesity changes. We examined associations of mppBMI and GWG with longitudinal change in offspring's BMI (ΔBMI), and assessed whether associations are explained by offspring genetics. We used a birth cohort of 1400 adults, with data at birth, age 17 and 32. After genotyping offspring, we created genetic scores, predictive of exposures and outcome, and fit linear regression models with and without scores to examine the associations of mppBMI and GWG with ΔBMI. A one SD change in mppBMI and GWG was associated with a 0.83 and a 0.75 kg/m2 increase in ΔBMI respectively. The association between mppBMI and offspring ΔBMI was slightly attenuated (12%) with the addition of genetic scores. In the GWG model, a significant substantial 28.2% decrease in the coefficient was observed. This study points to an association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood. Genetic factors may account, in part, for the GWG/ΔBMI association. These findings broaden observations that maternal obesity-related phenotypes have long-term consequences for offspring health.
登录
查看更多内容
DOI：
10.1002/j.1550-8528.1997.tb00559.x
发表时间：
1997-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Austin, MA;Friedlander, Y;King, MC
通讯作者：
King, MC
影响因子：
--
作者：
Gross, Revital;Brammli-Greenberg, Shuli;Afek, Arnon
通讯作者：
Afek, Arnon
影响因子：
39.3
作者：
Rosengren, A;Wedel, H;Wilhelmsen, L
通讯作者：
Wilhelmsen, L
影响因子：
158.5
作者：
LISSNER, L;ODELL, PM;BROWNELL, KD
通讯作者：
BROWNELL, KD
DOI：
10.1016/s1083-3188(00)86618-8
发表时间：
1999-02-01
影响因子：
1.8
作者：
Biro, F M;Wiley-Kroner, B;Whitsett, D
通讯作者：
Whitsett, D