Treatment of psoriatic arthritis by extracorporeal photochemotherapy
Treatment of psoriatic arthritis by extracorporeal photochemotherapy
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体外光化疗治疗银屑病关节炎
DOI：
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发表时间：
1990
影响因子：
10.3
通讯作者：
K. Wolff
中科院分区：
文献类型：
--
作者：
H. Wilfert;H. Hönigsmann;G. Steiner;J. Smolen;K. Wolff
五名患有长期血清阴性关节炎且对常规治疗耐药并且还患有皮肤银屑病的患者接受了光采术治疗。这种治疗模式将淋巴细胞富集手术与 8-甲氧基补骨脂素光化疗相结合。对处理过的淋巴细胞有显着的体外影响，其活力、增殖和有丝分裂原反应均降低。五名患者中的四名在握力、肿胀、疼痛、晨僵、非甾体类抗风湿药物的剂量和放射学变化方面有轻微到中度的临床改善。皮肤损伤对光采术没有反应。短期副作用很小，包括治疗后立即出现眼睛暂时对光敏感和循环失调的迹象。这种实验疗法在改善银屑病关节病方面具有一些可测量但不显着的效果。
Five patients with long‐standing seronegative arthritis resistant to conventional therapy and who also had psoriasis of the skin were treated with photopheresis. This mode of treatment combines a lymphocyte‐enrichment procedure with 8–methoxypsoralen‐photochemotherapy. There was a marked in vitro effect on treated lymphocytes, with a reduction of viability, proliferation and mitogen response. There was a slight to moderate clinical improvement in four of the five patients with regard to the strength of grip, swelling, pain, morning stiffness, the dosage of non‐steroidal anti‐rheumatic drugs and the radiographical changes. The skin lesions did not respond to photopheresis. Short‐term side‐effects were minimal and consisted of a temporary sensitivity of the eyes to light and signs of circulatory dysregulation immediately after treatment. This experimental therapy has some measurable but not dramatic effect in improving psoriatic arthropathy.
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通过输注同基因光灭活效应淋巴细胞抑制抗皮肤同种异体移植免疫。
DOI：
10.1111/1523-1747.ep12696853
发表时间：
1989
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Perez,M;Edelson,R;Laroche,L;Berger,C
通讯作者：
Berger,C
寻常型银屑病中表型辅助细胞、抑制细胞和总 T 细胞群的正常数量：通过单克隆抗体进行定量。
影响因子：
13.8
作者：
DePietro,WP;Berger,CL;Harber,LC;Edelson,RL
通讯作者：
Edelson,RL
影响因子：
158.5
作者：
EDELSON, R;BERGER, C;LAROCHE, L
通讯作者：
LAROCHE, L
经过 8-甲氧基补骨脂素和紫外线 A 光修饰的 DNA 单克隆抗体。
影响因子：
14.9
作者：
Santella,RM;Dharmaraja,N;Gasparro,FP;Edelson,RL
通讯作者：
Edelson,RL