Newly identified chemotherapy-induced peripheral neuropathy in a childhood cancer survivorship clinic.

Newly identified chemotherapy-induced peripheral neuropathy in a childhood cancer survivorship clinic.
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DOI:
10.1002/pbc.29550
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发表时间:
2022-03
影响因子:
3.2
通讯作者:
Kadan-Lottick NS
Kadan-Lottick NS
中科院分区:
医学3区
文献类型:
--
作者:
Rodwin RL;Ross WL;Rotatori J;Allen K;Auerbach C;Balsamo LM;Kadan-Lottick NS

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化疗引起的周围神经病变(CIPN)是儿童癌症治疗的一种使人衰弱的副作用,诊断起来具有挑战性。我们估计了新发现的和以前诊断的CIPN在地区HEROS儿童癌症幸存者诊所的患病率。从2016年至2018年,148名幸存者(45.3%为女性,年龄17.1 [SD 7.7]岁,81.8%为正在进行的常规肿瘤随访)在诊断后平均7.4 (SD 6.6)年进行了初始生存评估。56名幸存者(37.8%)患有CIPN,其中46名(82.1%)为新发现的患者。我们的研究结果表明,CIPN可能在常规肿瘤护理中被遗漏,需要新的方法来筛查CIPN。
Chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect of pediatric cancer therapy, can be challenging to diagnose. We estimated the prevalence of newly identified and previously diagnosed CIPN in the regional HEROS Childhood Cancer Survivorship Clinic. From 2016-2018, 148 survivors (45.3% female, age 17.1 [SD 7.7] years, 81.8% in ongoing routine oncology follow-up) had their initial survivorship evaluation at an average of 7.4 (SD 6.6) years from diagnosis. Fifty-six survivors (37.8%) had CIPN, of these 46 (82.1%) were newly identified. Our findings demonstrate CIPN may be missed in routine oncology care, and new methods are needed to screen for CIPN.
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发表时间: 2018-08-01
期刊: JAMA NEUROLOGY
影响因子: 29
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