Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations.
Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations.
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DOI：
10.1155/2007/942650
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Stockfleth E
中科院分区：
文献类型：
--
作者：
Nindl I;Gottschling M;Stockfleth E
人乳头瘤病毒（HPV）感染皮肤和粘膜上皮，诱发良性和恶性病变。非黑色素瘤皮肤癌（NMSC），包括基底细胞癌和鳞状细胞癌（SCC），是高加索人群中最常见的癌症，其发病率在全球范围内急剧增加。紫外线（UV）辐射是NMSC的主要危险因素，皮肤HPV也被认为在这些癌症的发病过程中发挥积极作用。在疣状表皮发育不良（EV）患者中报道了HPV参与NMSC的第一个证据。在这些患者的皮肤肿瘤中检测到的HPV类型被称为EV/皮肤HPV类型，属于β和γ乳头瘤病毒（PV）。流行病学研究表明，NMSC的几种EV/皮肤HPV类型的风险较高。此外，体外和动物模型显示一些PV类型的转化特性。一些EV/皮肤HPV E6蛋白对紫外线诱导突变的抗凋亡活性和DNA修复机制的延迟可能导致DNA损伤的角化细胞持续存在。因此，与紫外线辐射和免疫系统相关的特定EV/皮肤HPV类型似乎参与了皮肤SCC的早期发病机制。
Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldwide. Ultraviolet (UV) radiation is a major risk factor for NMSC, and cutaneous HPV is also considered to play an active role during the pathogenesis of these cancers. The first evidence for the involvement of HPV in NMSC was reported in patients with Epidermodysplasia verruciformis (EV). HPV types detected in skin tumours of these patients are referred to as EV/cutaneous HPV types belonging to the beta- and gamma-papillomaviruses (PV). Epidemiological studies have shown a higher risk of several EV/cutaneous HPV types for NMSC. Furthermore, in vitro and animal models show transforming properties of some PV types. The anti-apoptotic activities, and the delay of DNA repair mechanism caused by some EV/cutaneous HPV E6 proteins in response to UV-induced mutations, may lead to the persistence of DNA-damaged keratinocytes. Thus, specific EV/cutaneous HPV types as co-factors in association with UV-radiation and the immune system seem to be involved in the early pathogenesis of cutaneous SCC.
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影响因子：
64.8
作者：
AMTMANN, E;VOLM, M;WAYSS, K
通讯作者：
WAYSS, K
影响因子：
6.2
作者：
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通讯作者：
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DOI：
10.1016/s1011-1344(01)00198-1
发表时间：
2001-10-01
影响因子：
5.4
作者：
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158.5
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影响因子：
6.4
作者：
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通讯作者：
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