Depression in Chronic Kidney Disease and End-Stage Renal Disease: Similarities and Differences in Diagnosis, Epidemiology, and Management.
Depression in Chronic Kidney Disease and End-Stage Renal Disease: Similarities and Differences in Diagnosis, Epidemiology, and Management.
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DOI：
10.1016/j.ekir.2016.09.005
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发表时间：
2017-01
影响因子：
6
通讯作者：
Ricardo AC
中科院分区：
文献类型：
--
作者：
Shirazian S;Grant CD;Aina O;Mattana J;Khorassani F;Ricardo AC
抑郁症在成人慢性肾脏疾病（CKD）患者（包括终末期肾脏疾病（ESRD））中非常普遍，并与生活质量差和死亡率增加相关。然而，非透析依赖型CKD和ESRD患者在抑郁症的诊断、流行病学和管理方面存在一些重要差异。了解这些差异可能有助于更好地了解这两种不同人群的抑郁症。首先，与CKD患者相比，ESRD患者使用自我报告问卷诊断抑郁症的准确性可能较低。第二，尽管两组中基于访谈的抑郁症患病率约为20%，但抑郁症的风险因素可能有所不同。第三，CKD和ESRD中抑郁的潜在机制也可能不同。最后，考虑到抗抑郁药物的类型和剂量在CKD和ESRD之间有所不同。未来的研究应该进一步研究这两组的抑郁机制，并测试干预措施来预防和治疗这些人群的抑郁。
Depression is highly prevalent and is associated with poor quality of life and increased mortality among adults with chronic kidney disease (CKD), including those with end-stage renal disease (ESRD). However, there are several important differences in the diagnosis, epidemiology, and management of depression between patients with non−dialysis-dependent CKD and ESRD. Understanding these differences may lead to a better understanding of depression in these 2 distinct populations. First, diagnosing depression using self-reported questionnaires may be less accurate in patients with ESRD compared with CKD. Second, although the prevalence of interview-based depression is approximately 20% in both groups, the risk factors for depression may vary. Third, potential mechanisms of depression might also differ in CKD versus ESRD. Finally, considerations regarding the type and dose of antidepressant medications vary between CKD and ESRD. Future studies should further examine the mechanisms of depression in both groups, and test interventions to prevent and treat depression in these populations.
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