Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018.
Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018.
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DOI：
10.1136/bmj.n251
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发表时间：
2021-02-17
期刊：
影响因子：
--
通讯作者：
Turner PJ
中科院分区：
文献类型：
--
作者：
Baseggio Conrado A;Ierodiakonou D;Gowland MH;Boyle RJ;Turner PJ
描述过去20年英国因食物过敏反应住院的时间趋势。1998-2018年国家数据分析。与速发过敏反应和死亡相关的住院数据，以及肾上腺素自动注射装置的处方数据。英国人口作为一个整体和下放国家（英格兰，苏格兰，威尔士和北方爱尔兰）。因食物和非食物触发物引起的过敏反应而入院的时间趋势、年龄和性别分布，以及这些入院率与病死率（死亡人数占入院人数的比例）的比较。在1998年至2018年期间，有101891人因过敏反应入院。在这些入院者中，30700人（30.1%）被编码为食物触发。食物过敏入院从1998年每10万人每年1.23例增加到2018年每10万人每年4.04例，年增长5.7%（95%置信区间5.5%~ 5.9%，P<0.001）。15岁以下儿童的住院人数增加最多，从每年每10万人2.1人增加到9.2人（年增长6.6%，95%置信区间6.3%至7.0%）。相比之下，15-59岁人群的年增长率为5.9%（5.6%至6.2%），60岁及以上人群为2.1%（1.8%至3.1%）。确定了152例死亡，其中致死性事件可能由食物诱导的速发型过敏反应引起。确诊致命性食物过敏反应的病死率从0.7%降至0.19%（率比0.931，95%可信区间0.904 ~ 0.959，P<0.001），疑似致命性食物过敏反应的病死率从0.970，0.945 ~ 0.996，P=0.024）降至0.30%。至少46%（187人中的86人，其中包括1992-98年的35人）的死亡是由花生或坚果引发的。牛奶导致66名学龄儿童中的17名（26%）死亡。在同一时期，肾上腺素自动注射器的处方增加了336%（估计率比1.113，95%置信区间1.112至1.113;每年增加11%）。从1998年到2018年，食物引起的过敏反应的住院人数有所增加，但病死率有所下降。在学龄儿童中，牛奶现在是致命过敏反应的最常见单一原因。
To describe time trends for hospital admissions due to food anaphylaxis in the United Kingdom over the past 20 years. Analysis of national data, 1998-2018. Data relating to hospital admissions for anaphylaxis and deaths, and prescription data for adrenaline autoinjector devices. UK population as a whole and devolved nations (England, Scotland, Wales, and Northern Ireland). Time trends, age, and sex distributions for hospital admissions for anaphylaxis due to food and non-food triggers, and how these admission rates compare with the case fatality rate (number of fatalities as a proportion of hospital admissions). Between 1998 and 2018, 101 891 people were admitted to hospital for anaphylaxis. Of these admissions, 30 700 (30.1%) were coded as due to a food trigger. Food anaphylaxis admissions increased from 1.23 to 4.04 per 100 000 population per year (from 1998 to 2018), an annual increase of 5.7% (95% confidence interval 5.5% to 5.9%, P<0.001). The largest increase in hospital admissions was observed in children younger than 15 years, with an increase from 2.1 to 9.2 admissions per 100 000 population per year (an annual increase of 6.6%, 95% confidence interval 6.3% to 7.0%). For comparison, the annual increase was 5.9% (5.6% to 6.2%) in people aged 15-59 years and 2.1% (1.8% to 3.1%) in those aged 60 years and older. 152 deaths were identified where the fatal event was probably caused by food induced anaphylaxis. The case fatality rate decreased from 0.7% to 0.19% for confirmed fatal food anaphylaxis (rate ratio 0.931, 95% confidence interval 0.904 to 0.959, P<0.001) and to 0.30% for suspected fatal food anaphylaxis (0.970, 0.945 to 0.996, P=0.024). At least 46% (86 of 187, which also includes 35 deaths in 1992-98) of deaths were triggered by peanut or tree nut. Cow’s milk was responsible for 17 of 66 (26%) deaths in school aged children. Over the same time period, prescriptions for adrenaline autoinjectors increased by 336% (estimated rate ratio 1.113, 95% confidence interval 1.112 to 1.113; an increase of 11% per year). Hospital admissions for food induced anaphylaxis have increased from 1998 to 2018, however the case fatality rate has decreased. In school aged children, cow’s milk is now the most common single cause of fatal anaphylaxis.
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影响因子：
3.7
作者：
Tanno LK;Chalmers RJ;Calderon MA;Aymé S;Demoly P;on behalf the Joint Allergy Academies
通讯作者：
on behalf the Joint Allergy Academies
影响因子：
14.2
作者：
Grabenhenrich, Linus B.;Doelle, Sabine;Worm, Margitta
通讯作者：
Worm, Margitta
影响因子：
4.4
作者：
Hoffer, V.;Scheuerman, O.;Garty, B. Z.
通讯作者：
Garty, B. Z.
影响因子：
5.1
作者：
Turner, Paul J.;Worm, Margitta;Cardona, Victoria
通讯作者：
Cardona, Victoria
影响因子：
12.4
作者：
Jensen-Jarolim E;Untersmayr E
通讯作者：
Untersmayr E